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Training an AI Scientist with Feedback from Reality, w- Liam Fedus & Ekin Dogus Cubuk (from a16z)

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October 2, 2025
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Cognitive Revolution "How AI Changes Everything"
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Training an AI Scientist with Feedback from Reality, w- Liam Fedus & Ekin Dogus Cubuk (from a16z)

TL;DR

Periodic Labs integrates AI with real-world experiments to advance scientific discovery.

Transcript

Hello and welcome back to the cognitive revolution. Today I'm pleased to share a special crossost from the A16Z podcast featuring A16Z general partner Anjene Mida who also recently joined me on the cognitive revolution to discuss sovereign AI. Today in conversation with Liam Fetis, former VP of post- training research and co-creator of chat GPT at ... Read More

Key Insights

  • Periodic Labs aims to accelerate scientific discovery by integrating AI with real-world experiments, creating a 'physically grounded reward function' that relies on actual experimental data rather than digital simulations.
  • The lab's focus is on training AI models in physics and chemistry, using language models coupled with automated materials synthesis to potentially discover room-temperature superconductors.
  • Periodic Labs is distinct from traditional AI labs by including physical experimentation facilities, allowing AI systems to conduct tests and gather data from real-world experiments.
  • The founders, Liam Fedus and Ekin Dogus Cubuk, emphasize the importance of iterative scientific inquiry, where AI models learn through cycles of simulation, theoretical calculations, and real-world experiments.
  • Periodic Labs has set a north star goal of discovering a high-temperature superconductor, which involves achieving numerous sub-goals such as autonomous synthesis and characterization.
  • The lab seeks to create a collaborative environment where physicists, chemists, and ML researchers learn from each other, fostering a culture of curiosity and mission alignment without requiring advanced degrees.
  • Periodic Labs plans to commercialize its progress by offering an intelligence layer for advanced manufacturing companies and starting a grant program to support academic contributions.
  • The lab believes that advancing AI in scientific domains can lead to significant breakthroughs in industries like space, defense, and semiconductors, by reducing iteration times and improving material properties.

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Questions & Answers

Q: What is the main innovation of Periodic Labs?

Periodic Labs' main innovation is the creation of a 'physically grounded reward function' by integrating real-world experiments directly with AI systems. This approach allows AI models to learn from actual experimental data, unlike traditional AI labs that rely on digital simulations.

Q: How does Periodic Labs differ from traditional AI labs?

Periodic Labs differs from traditional AI labs by including physical experimentation facilities where AI systems can conduct tests and gather data from real-world experiments. This integration of physical labs allows for a more accurate training of AI models in scientific domains like physics and chemistry.

Q: What is the goal of Periodic Labs in terms of scientific discovery?

Periodic Labs aims to discover a high-temperature superconductor as its north star goal. This involves achieving numerous sub-goals such as autonomous synthesis and characterization, ultimately accelerating scientific progress in fields like material science and chemistry.

Q: How does Periodic Labs plan to commercialize its progress?

Periodic Labs plans to commercialize its progress by offering an intelligence layer for advanced manufacturing companies. Additionally, they intend to start a grant program to support academic contributions, thereby fostering collaboration between industry and academia.

Q: What kind of culture does Periodic Labs promote?

Periodic Labs promotes a culture of curiosity and mission alignment, where physicists, chemists, and ML researchers learn from each other. They prioritize intense curiosity and do not require advanced degrees, fostering an environment where no questions are considered stupid.

Q: Why is Periodic Labs focused on room-temperature superconductors?

Periodic Labs is focused on room-temperature superconductors because discovering one would be a significant scientific breakthrough with broad applications. It would provide new insights into quantum mechanics and potentially transform industries like energy, transportation, and electronics.

Q: What industries could benefit from Periodic Labs' breakthroughs?

Industries such as space, defense, and semiconductors could benefit from Periodic Labs' breakthroughs. By reducing iteration times and improving material properties, the lab's advancements could accelerate R&D and lead to significant technological innovations in these fields.

Q: How does Periodic Labs plan to support academic contributions?

Periodic Labs plans to support academic contributions by starting a grant program, even at its early stage. This initiative aims to elicit key contributions from academia, fostering collaboration and ensuring that the lab's advancements benefit the broader scientific community.

Summary & Key Takeaways

  • Periodic Labs is pioneering a novel approach to AI-driven scientific discovery by integrating real-world experiments into the training of AI models. This approach aims to create a 'physically grounded reward function' that relies on actual experimental data, setting it apart from traditional AI labs that focus on digital simulations.

  • The lab's founders, Liam Fedus and Ekin Dogus Cubuk, emphasize the importance of iterative scientific inquiry, where AI models learn through cycles of simulation, theoretical calculations, and real-world experiments. Their goal is to discover a high-temperature superconductor, which involves achieving numerous sub-goals such as autonomous synthesis and characterization.

  • Periodic Labs plans to commercialize its progress by offering an intelligence layer for advanced manufacturing companies and starting a grant program to support academic contributions. The lab believes that advancing AI in scientific domains can lead to significant breakthroughs in industries like space, defense, and semiconductors.


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