What Businesses Thrive in the AI Era?

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October 6, 2026
by
Greg Isenberg
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What Businesses Thrive in the AI Era?

TL;DR

In the age of AI, 13 types of businesses stand out as promising ventures. These include AI-native service firms, offline businesses, and proprietary data sets, among others. Each offers unique opportunities by leveraging AI technology, meeting niche demands, or providing essential resources like data and energy. Understanding these opportunities can position entrepreneurs for success in a rapidly evolving digital landscape.

Transcript

Today we're going to talk about the only businesses left to build in the agentic era. Yes, I think that there's only 13 businesses to be building in the world of agents. Now, I don't subscribe to the people who say there's going to be this permanent underclass and you just got to create businesses or else you're kind of messed up for the future. I ... Read More

Key Insights

  • AI-native service firms rely on agents for most tasks, with human oversight for exceptions, offering high margins and efficiency.
  • Offline businesses thrive by providing unique, in-person experiences that technology alone cannot replicate, such as wellness and community-focused ventures.
  • Building organic audiences is crucial as ad costs have significantly increased, making distribution and audience ownership valuable.
  • Proprietary data sets and domain-specific harnesses are emerging as lucrative areas, with data becoming a highly valuable commodity.
  • Robotics and physical AI are closer to mainstream adoption than many realize, offering innovative service solutions like automated window cleaning.
  • Physical products with niche fan followings, such as specialty coffee equipment, demonstrate the potential for high-margin, targeted consumer goods.
  • Compute and energy are essential resources for AI agents, with significant investments being made in infrastructure to support AI growth.
  • Security in the AI era involves both software solutions and physical security services, addressing the increasing risks of data breaches and personal safety.

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Questions & Answers

Q: How do AI-native service firms operate efficiently?

AI-native service firms operate efficiently by utilizing agents to perform the majority of tasks, with human oversight limited to reviewing exceptions. This approach allows for high-margin operations and scalability, as agents can handle repetitive and data-driven tasks effectively, reducing the need for extensive human labor. Examples include bookkeeping services where agents prepare records, and humans handle exceptions, ensuring accuracy and compliance.

Q: Why are offline businesses still relevant in the AI era?

Offline businesses remain relevant in the AI era because they fulfill the human desire for physical and social experiences that cannot be entirely replicated by technology. These businesses, such as wellness centers or community hubs, provide unique environments and interactions that enhance customer satisfaction and loyalty. Despite the digital shift, the demand for tangible experiences ensures the continued success of well-conceived offline ventures.

Q: What makes proprietary data sets valuable in today's market?

Proprietary data sets are valuable because they provide unique insights that are not readily available through standard AI models or public data sources. As AI technology advances, the demand for exclusive data to train and refine models increases, creating opportunities for businesses to collect, manage, and sell specialized data. This value is amplified by the competitive advantage such data can offer in developing innovative solutions and products.

Q: How are domain-specific harnesses different from general AI models?

Domain-specific harnesses differ from general AI models by being tailored to specific industries or applications, incorporating specialized tools, workflows, and data to optimize performance. While general AI models provide broad capabilities, harnesses focus on enhancing functionality within a particular context, such as freight brokerage or legal services, by integrating industry-specific knowledge and processes. This specialization allows for more effective and efficient solutions in targeted domains.

Q: What opportunities exist in robotics and physical AI?

Opportunities in robotics and physical AI include developing automated solutions for tasks traditionally performed by humans, such as window cleaning or delivery services. As technology advances, these solutions become more feasible and cost-effective, offering businesses the chance to innovate in service delivery and operations. Robotics also opens avenues for collaboration between software and hardware, creating integrated systems that enhance efficiency and reduce operational costs.

Q: Why are niche physical products gaining popularity?

Niche physical products are gaining popularity because they cater to specific interests and communities, offering unique features that resonate with targeted audiences. These products, such as specialty coffee equipment, often command higher prices due to their perceived value and quality. Advances in AI and manufacturing enable the creation and customization of such products, allowing businesses to tap into passionate consumer bases and foster brand loyalty.

Q: How do compute and energy factor into AI business models?

Compute and energy are critical components of AI business models as they provide the necessary infrastructure for running AI agents and processing data. With the increasing demand for AI applications, businesses that can supply or manage these resources, such as data centers or energy-efficient solutions, are well-positioned to capitalize on the growing need for reliable and scalable computing power. Investments in these areas ensure the sustainability and expansion of AI capabilities.

Q: What role does security play in the agentic era?

Security plays a vital role in the agentic era by protecting sensitive data and ensuring the integrity of AI systems. As reliance on AI grows, the risk of data breaches and cyber threats increases, making security solutions critical for safeguarding information and maintaining trust. Businesses focusing on software security, such as access control and encryption, as well as physical security services, are essential in addressing these challenges and ensuring the safe deployment of AI technologies.

Summary & Key Takeaways

  • AI-native service firms leverage agents for task execution, requiring minimal human intervention, which results in high efficiency and profitability. These firms are positioned to thrive by capitalizing on advanced AI models and offering services like bookkeeping and creative agencies.

  • Offline businesses capitalize on the human desire for physical experiences, providing services that are enhanced by, but not reliant on, AI. These businesses, such as wellness centers or community hubs, offer unique value propositions through in-person interactions.

  • The demand for proprietary data sets and domain-specific harnesses is growing, as data becomes a critical asset in the AI landscape. Businesses that can acquire and utilize unique data have a competitive edge, making data collection and management a promising venture.


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