What Startup Opportunities Are Worth Building Now?

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May 18, 2026
by
Greg Isenberg
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What Startup Opportunities Are Worth Building Now?

TL;DR

The strongest startup opportunities replace passive software with useful action, serve overlooked groups, or create authentic human connection. Promising directions include agent-first apps, live creator shows, communities, elder technology, adult hobbies, personalized health, pet care, and AI-native media, with the best concepts often combining several of these themes around a specific audience.

Transcript

I have one goal and one goal only today. It's to go through the 12 biggest startup opportunities. So, uh, the other day I tweeted and it went viral. The 30 best biggest startup opportunities, B TOC, AI, mobile, and people just wanted more. They they wanted they wanted to know more. So, in this episode, I want to go through my 12 favorite ones. And ... Read More

Key Insights

  • Live, unscripted shows are a creator opportunity because audiences can watch authentic conversations, mistakes, and reactions unfold in real time. The format adapts established gaming-stream behavior to valuable professional audiences that may be underserved by highly edited interviews and polished business podcasts.
  • A focused live audience can support a meaningful business through direct relationships with the creator. The discussed revenue options include paid access, memberships, merchandise, and in-person events, reducing the need to depend entirely on advertising or exceptionally large audience reach.
  • Action apps are agent-first products that complete tasks instead of presenting another interface for users to manage. Examples discussed include clearing an inbox, booking a calendar, and filing expenses, with AI acting on the user's behalf after learning how the user prefers work to be handled.
  • Agent-first software creates an opening for new companies because established products may struggle to redesign experiences built around manual interaction. The transition is compared with the earlier shift from web-first products to mobile-first products, when new entrants could design directly for the emerging behavior.
  • Fully automated products can face a retention challenge when their value becomes invisible. If software runs quietly in the background, customers may forget what it accomplishes and question recurring charges, suggesting that useful progress reports or limited interaction may help communicate continuing value.
  • Human connection is a startup theme that includes loneliness, in-person communities, third places, adult hobbies, and retreats. These opportunities respond to demand for belonging and shared experiences that software alone cannot provide, while also creating room for memberships, events, and specialized communities.
  • Underserved audiences create multiple focused opportunities, including older adults, small businesses, health-conscious consumers, and pet owners. The proposed products range from elder technology and AI junior employees to personalized nutrition, human health tools, and AI-supported animal care.
  • AI-native media is strongest when artificial intelligence supports a distinctive audience proposition instead of merely producing generic material. The broader discussion favors combining AI efficiency with human judgment, trusted personalities, specialized communities, or live experiences that remain difficult to sanitize or automate completely.

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Questions & Answers

Q: How can an unscripted live show become a business?

An unscripted live show can become a business by serving a focused audience that values the host's knowledge, personality, and direct interaction. Revenue can come from paid access, memberships, merchandise, and in-person events. The discussion emphasizes that a creator does not necessarily need a massive audience when viewers have strong affinity and meaningful commercial value.

Q: Why are live creator shows attractive in an AI-heavy media market?

Live creator shows offer visible humanity through spontaneous comments, audience reactions, mistakes, and unpredictable moments. These qualities contrast with media that feels polished, scripted, or sanitized by AI. Long-form streaming can therefore differentiate a creator by making the relationship with viewers feel immediate, authentic, and difficult to reproduce through automated content production.

Q: What is an AI agent-first action app?

An AI agent-first action app is software designed to complete work for the user instead of waiting for repeated manual input. The examples discussed include clearing an inbox, managing calendar bookings, and filing expenses. Its defining feature is action: the agent learns preferences and performs useful tasks rather than simply displaying information or asking the user to click through workflows.

Q: Why could startups outperform existing software companies with action apps?

Startups can design around autonomous agents from the beginning, while established software companies may need to transform products built for manual interaction. The discussion compares this opening with the move from web-first to mobile-first products. A new entrant can rethink the complete experience around delegated action instead of adding automation to an interface that still expects users to do the work.

Q: How can an automated app show enough value to retain customers?

An automated app must make its continuing contribution understandable even when it requires little attention. The discussion raises the risk that customers may forget a background service is working and reconsider it when they see a recurring bill. A product can address this tension by communicating completed actions, outcomes, or progress while preserving the convenience of automation.

Q: What startup opportunities address loneliness and weak social connection?

Businesses can address loneliness by creating in-person communities, third places, hobby groups, retreats, and recurring experiences organized around a shared identity or interest. The opportunity is not merely to connect people online, but to give them a dependable reason and setting to meet. These concepts can also be combined with creator audiences or entrepreneurial communities.

Q: Which underserved audiences are highlighted as startup opportunities?

The highlighted audiences include older adults, small businesses, people seeking personalized nutrition or health support, adult hobbyists, and pet owners. Each group has needs that can support specialized products rather than broad generic tools. The proposed directions include elder technology, AI junior employees, hobby experiences, individualized health services, and AI-assisted animal health products.

Q: How should founders choose among these startup ideas?

Founders should look for a specific audience they understand deeply and a problem they are willing to stay committed to. The discussion encourages builders to pressure-test a niche, consider how it creates value, and examine whether multiple themes can be stacked together. One example combines live content, retreats, and an entrepreneurial audience into a more differentiated business.

Summary & Key Takeaways

  • The discussion identifies startup opportunities across software, media, health, and physical communities. Its central framework is to find valuable audiences whose needs remain poorly served, then build products that either perform work automatically or create experiences people cannot obtain from polished, passive, and increasingly automated digital content.

  • Live creator shows apply the Twitch model to business and technology audiences through long, unscripted broadcasts. Their appeal comes from direct interaction, unpredictability, and visible human personality. Even a relatively small but valuable audience can support memberships, merchandise, events, and other offerings connected to the host's subject matter.

  • Other opportunities include agent-first action apps, communities addressing loneliness, technology designed for older adults, adult hobby businesses, AI employees for small businesses, personalized nutrition and health, pet health tools, and AI-native media. These ideas can also be combined, such as pairing live entrepreneurial content with in-person retreats.


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