Epigenetics & the Human Brain: The Intersection of Genetics and Mental Health


Hatched by Glasp

Jul 13, 2023

4 min read


Epigenetics & the Human Brain: The Intersection of Genetics and Mental Health

"Epigenetics & the Human Brain" sheds light on the fascinating relationship between our genetic makeup and our mental well-being. It explores how epigenetic modifications, which can be influenced by both genetic and environmental factors, play a crucial role in shaping the functioning of our brain. This article highlights some intriguing findings in the field of epigenetics and their implications for understanding mental health disorders such as suicide, schizophrenia, and the effects of drug abuse.

One of the most striking discoveries is the difference in ribosomal RNA (rRNA) gene activity between individuals who die by suicide and those who die of other causes. People who commit suicide tend to have less-active rRNA genes, resulting in reduced protein production. This finding suggests a potential link between rRNA gene activity and the risk of suicide, emphasizing the importance of studying epigenetic markers in mental health disorders.

Furthermore, the article explores the impact of child abuse on the epigenetic marks in the brain. Comparing suicide victims who were abused with those who were not, it was found that only the abused victims had an epigenetic tag on the GR gene. This gene is involved in regulating stress responses, and its altered activity due to epigenetic changes may contribute to the heightened vulnerability of abused individuals to mental health issues.

Another gene of interest is the REELIN gene, which plays a crucial role in brain development and learning. In schizophrenic brains, the REELIN gene exhibits increased methylation, indicating reduced activity. This finding suggests that epigenetic modifications to the REELIN gene may contribute to the disrupted brain development and cognitive impairments observed in individuals with schizophrenia.

The article also delves into the effects of drug abuse on the epigenome. Drugs such as cocaine have been found to induce widespread epigenetic changes in specific brain regions, affecting hundreds of genes simultaneously. These changes can persist long after the drug has left the system, potentially contributing to the long-term effects of drug abuse on mental health and behavior.

Moving on from the intricate world of epigenetics, the article transitions into the realm of success and hard work. It presents the notion that absolute success is largely attributed to luck, while relative success is predominantly influenced by hard work. The extraordinary story of Tu Youyou exemplifies the power of hard work. Despite lacking formal credentials, she dedicated her life to research and ultimately discovered a groundbreaking treatment for malaria. Tu's story serves as a reminder that hard work and persistence can lead to exceptional achievements.

The article emphasizes that luck plays a greater role in extreme success, while hard work becomes more significant in more localized comparisons. It highlights the importance of habits and choices in shaping our success trajectory. As Nassim Taleb suggests, "Mild success can be explainable by skills and labor. Wild success is attributable to variance." In other words, while luck may determine the magnitude of success, it is the individual's dedication and pursuit of opportunities that increase the likelihood of stumbling upon a lucky break.

To conclude, this article has explored the fascinating intersection of epigenetics and the human brain, shedding light on the role of epigenetic modifications in mental health disorders. It has also discussed the relationship between absolute and relative success, emphasizing the importance of hard work and persistence. To harness these insights and apply them to our lives, here are three actionable pieces of advice:

  • 1. Cultivate a strong work ethic: Success often requires sustained effort and determination. By developing a strong work ethic, you increase your chances of achieving your goals and making the most of any lucky breaks that come your way.
  • 2. Embrace opportunities: Actively seek out opportunities and be open to trying new things. The more you explore and expose yourself to different experiences, the higher the likelihood of encountering a lucky break that can propel you towards success.
  • 3. Focus on your trajectory, not just outcomes: Instead of solely fixating on immediate results, focus on the habits and choices that shape your long-term trajectory. Consistent progress and improvement are key to achieving sustainable success.

Remember, luck may play a role, but it is your hard work, persistence, and willingness to seize opportunities that will ultimately pave the way for your success.

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