"The Intriguing Connection Between Epigenetics, Creativity, and Individuality"


Hatched by Glasp

Aug 14, 2023

4 min read


"The Intriguing Connection Between Epigenetics, Creativity, and Individuality"


The human brain is a complex organ that continually surprises us with its intricate workings and the multitude of factors that influence its development and function. In recent years, two seemingly unrelated topics, epigenetics, and the value of being a creative weirdo, have emerged as fascinating areas of study. Surprisingly, a closer examination reveals some intriguing commonalities between these seemingly disparate fields.

Epigenetics & the Human Brain:

Epigenetics, the study of changes in gene expression that do not involve alterations in the DNA sequence, has shed light on the impact of environmental factors on the human brain. Researchers have discovered fascinating connections between epigenetic marks and mental health, such as suicide and schizophrenia.

One study found that individuals who committed suicide had less-active ribosomal RNA (rRNA) genes compared to those who died of other causes. Furthermore, in the brains of suicide victims, methyl levels were higher on rRNA genes in the hippocampus, a crucial region for learning and memory. This increased methylation led to reduced rRNA production, resulting in fewer ribosomes and less protein production. Additionally, child abuse was found to leave an epigenetic mark on the brain, specifically on the GR gene, which was only observed in abused suicide victims.

In the case of schizophrenia, researchers discovered that the gene responsible for the production of the REELIN protein, crucial for brain development and learning, had higher levels of methylation in schizophrenic brains. This finding suggests a potential link between epigenetic regulation and the manifestation of this disorder.

The Value of Being a Creative Weirdo:

While the studies mentioned above delve into the biological underpinnings of the human brain, the concept of being a creative weirdo explores the psychological and societal implications of embracing one's uniqueness. Being perceived as strange or odd has often been associated with creative individuals, who possess a thinking style that falls outside the realm of societal norms.

As one grows older and wiser, the value of embracing one's weird persona becomes evident. Highly creative people, who refuse to conform to societal expectations, play a pivotal role in driving innovation and progress. They challenge the status quo and push the boundaries of what is deemed possible. By staying true to their authentic selves, creative individuals contribute to the collective growth of society.

Connecting Epigenetics and Individuality:

The connection between epigenetics and individuality becomes apparent when we consider the impact of environmental factors on gene expression. Epigenetic marks can be influenced by various external factors such as trauma, drug abuse, or even the creative process itself. For example, drugs of abuse, like cocaine, have been shown to trigger epigenetic changes in specific brain regions, affecting hundreds of genes. Remarkably, some of these changes persist long after the drug has left the system.

Similarly, the experiences and emotions that drive creative individuals to express their uniqueness may also leave epigenetic imprints on the brain. It is plausible that the very act of embracing one's creative weirdness can mold the epigenetic landscape, potentially influencing future generations.

Actionable Advice:

  • 1. Embrace Your Uniqueness: Instead of striving to fit in, celebrate what makes you different. Embracing your weirdness can foster creativity and lead to personal growth.
  • 2. Prioritize Authenticity: Avoid succumbing to societal pressure to conform. Focus on nurturing your authentic self and expressing your ideas and talents in ways that feel genuine to you.
  • 3. Explore Creative Outlets: Engaging in creative activities, whether it be painting, writing, or playing music, can provide a healthy outlet for self-expression and potentially contribute to the development of a unique epigenetic profile.


The connection between epigenetics, creativity, and individuality is a thought-provoking area of research that sheds light on the intricate workings of the human brain. By understanding how environmental factors and personal experiences influence gene expression, we can gain insights into mental health disorders and the importance of embracing our unique selves. As we navigate through life, let us celebrate our creative weirdness and nurture our authentic selves, for it is through these traits that we contribute to the enrichment of society.

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