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TL;DR

Bone hormone osteocalcin triggers fight or flight response independently of adrenal glands, shedding light on alternate stress pathways.

Transcript

{♫Intro♫} When you get scared or stressed, your body sets off what’s often called the “fight or flight” response—a series of changes which includes an increased heart rate and faster breathing. And for years, we’ve thought this response was kicked off by hormones from your adrenal glands. But research published yesterday in the journal Cell Metabol... Read More

Key Insights

• ☠️ Osteocalcin, a bone-derived hormone, triggers the fight or flight response independently of adrenal glands.
• ☠️ Research suggests that bone hormones play a significant role in the body's stress responses.
• 😟 The surge in osteocalcin levels during stress exposure activates the sympathetic nervous system response.
• 😟 Osteocalcin dampens parasympathetic nervous system activity, enabling the sympathetic response to function without opposition.
• ☠️ The study highlights the need for more research on bone hormones and their effects on the body.
• 🙂 Osteocalcin's role in stress pathways sheds light on the complex relationship between bones and stress responses.
• ☠️ Understanding bone hormones like osteocalcin can provide insights into novel stress response mechanisms.

Questions & Answers

Q: How does osteocalcin trigger the fight or flight response?

Osteocalcin triggers the response by dampening parasympathetic nervous system activity, allowing the sympathetic response to occur unopposed.

Q: What experiments supported the role of osteocalcin in stress response?

Studies on mice exposed to stress stimuli and injected with osteocalcin showed a surge in the hormone levels and activation of the fight or flight response.

Q: Why is osteocalcin's role in stress response significant?

Osteocalcin provides insights into an alternate stress pathway separate from adrenal responses, contributing to a deeper understanding of the body's stress mechanisms.

Q: What further research is needed in understanding bone hormones?

Further research is required to explore how bone hormones interact with adrenal responses and the brain to fully comprehend the brain and bone relationship.

Summary & Key Takeaways

• Research suggests a hormone released by bones, osteocalcin, triggers the fight or flight response independently of adrenal glands.

• Osteocalcin levels surge during stress and can activate the sympathetic nervous system response.

• The hormone dampens activity of the parasympathetic nervous system, allowing sympathetic response unopposed.