genken

genken

@genken

Hibernation/Hypothalamus/Sympathetic Neuron/PostDoc/movies

Joined Jan 19, 2023

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Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity - PubMed

pubmed.ncbi.nlm.nih.gov/17562860/

Dec 11, 2023

Constitutive endocytosis and degradation of CD22 by human B cells - PubMed

pubmed.ncbi.nlm.nih.gov/7722303/

CD22

Dec 11, 2023

1

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

www.cell.com/neuron/fulltext/S0896-6273(13)00316-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627313003164%3Fshowall%3Dtrue

Dec 10, 2023

32

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

www.frontiersin.org/articles/10.3389/fncel.2020.00162/full

シアル酸
CD22

Dec 8, 2023

43

GlycoWord / Immunity & Sugar Chain-IS-A06

www.glycoforum.gr.jp/glycoword/immunity/IS-A07J.html

CD22
シアル酸

Dec 8, 2023

63

第 35 話 シアル酸とは  ~シアル酸の構造 | 医化学創薬株式会社

soyaku.co.jp/info/2347/

シアル酸

Dec 8, 2023

11

糖質科学のことば / Glycolipid-A04

www.glycoforum.gr.jp/glycoword/glycolipid/GL-A04J.html

シアル酸

Dec 8, 2023

11

Siglecs in Brain Function and Neurological Disorders

www.mdpi.com/2073-4409/8/10/1125

CD22

Dec 8, 2023

11

CD22 Blockage Restores Age-Related Impairments of Microglia Surveillance Capacity

www.frontiersin.org/articles/10.3389/fimmu.2021.684430/full

CD22

Dec 8, 2023

1512

CD22 blockade restores homeostatic microglial phagocytosis in ageing brains - Nature

www.nature.com/articles/s41586-019-1088-4

CD22

Dec 8, 2023

117

Distinct tau folds initiate templated seeding and alter the post-translational modification profile

academic.oup.com/brain/advance-article/doi/10.1093/brain/awad272/7240187?login=true

alzheimer disease
tau phosphorylation
tau structure
tau

Nov 29, 2023

86

FEBS Press

febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13657

tau
tau structure
alzheimer disease

Nov 29, 2023

11

CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model | Proceedings of the National Academy of Sciences

www.pnas.org/doi/full/10.1073/pnas.2303760120

CD22

Nov 23, 2023

33

PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer

www.embopress.org/doi/full/10.15252/embj.2023113987

積読
Arf6

Nov 22, 2023

11

The ARF GTPase regulatory network in collective invasion and metastasis

portlandpress.com/biochemsoctrans/article/51/4/1559/233421/The-ARF-GTPase-regulatory-network-in-collective

Arf6

Nov 22, 2023

54

Identification of phosphorylated tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission

onlinelibrary.wiley.com/doi/10.1111/jnc.15796

tau
Arf6

Nov 22, 2023

22

シングルセル解析③:ダブレット推定手法について - Aurora blog

auroratummy.hatenablog.com/entry/2020/10/28/072113

scRNAseq

Nov 21, 2023

11

Hygromycin B Gold | Selection Antibiotic | InvivoGen

www.invivogen.com/hygromycin

Research tool

Nov 21, 2023

1

Hygromycin B Frequently Asked Questions

astralscientific.com.au/blogs/news/hygromycin-b-frequently-asked-questions

Research tool

Nov 21, 2023

2

細胞夜話 第11回番外編:LBの塩濃度 - バイオダイレクトメール vol.48

www.cytivalifesciences.co.jp/newsletter/biodirect_mail/cell_story/47_ext.html

Research tool

Nov 21, 2023

21

Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease - Nature Neuroscience

www.nature.com/articles/s41593-022-01251-x

Nov 20, 2023

1

染色体に取り込まれずに遺伝子を持続的に発現できるベクター(エピソーマルベクター) | Enhanced Episomal Vector (EEV) | フナコシ

www.funakoshi.co.jp/contents/63198

Research tool

Nov 19, 2023

1

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading - Molecular Psychiatry

www.nature.com/articles/s41380-020-0738-0

tau secretion
tau

Nov 18, 2023

11

ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis | Journal of Cell Biology | Rockefeller University Press

rupress.org/jcb/article/162/4/647/33350/ARF6-regulates-a-plasma-membrane-pool-of

Arf6

Nov 18, 2023

1

Role of ADP-ribosylation Factor 6 (ARF6) in Gastric Acid Secretion

www.sciencedirect.com/science/article/pii/S0021925820834590

Arf6

Nov 18, 2023

55

Coupling actin and membrane dynamics during calcium-regulated exocytosis: a role for Rho and ARF GTPases

www.sciencedirect.com/science/article/pii/S0167488904002460

Nov 6, 2023

1

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle - Nature Communications

www.nature.com/articles/s41467-020-14893-x

Arf6

Nov 5, 2023

11

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

www.mdpi.com/1422-0067/21/7/2576

lysosome
exocytosis

Nov 5, 2023

11

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation - PubMed

pubmed.ncbi.nlm.nih.gov/9663393/

Nov 5, 2023

11

A role for phospholipase D1 in neurotransmitter release - PubMed

pubmed.ncbi.nlm.nih.gov/11752468/

Arf6

Nov 5, 2023

11

Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network - PubMed

pubmed.ncbi.nlm.nih.gov/9245781/

Arf6

Nov 5, 2023

11

ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate | Proceedings of the National Academy of Sciences

www.pnas.org/doi/full/10.1073/pnas.2232129100

Arf6

Nov 5, 2023

11

Class II Arfs require a brefeldin-A-sensitive factor for Golgi association

www.sciencedirect.com/science/article/abs/pii/S0006291X20313784

Nov 5, 2023

1

非アポトーシス細胞死を研究する | アブカム

www.abcam.co.jp/cancer/studying-non-apoptotic-cell-death

JC

Nov 2, 2023

11

MLKL ~ネクロトーシスのキープレーヤー | アブカム

www.abcam.co.jp/primary-antibodies/antibody-focus-mlkl-1

JC

Nov 2, 2023

31

Soluble CD22 as a tumor marker for hairy cell leukemia

ashpublications.org/blood/article/112/6/2272/24868/Soluble-CD22-as-a-tumor-marker-for-hairy-cell

CD22

Oct 29, 2023

11

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine - Nature

www.nature.com/articles/nature14972

GLRA1

Oct 23, 2023

1

Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease - Genome Medicine

genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01136-5

Oct 21, 2023

1

Gene therapy: progress and predictions - PubMed

pubmed.ncbi.nlm.nih.gov/26702034/

Oct 13, 2023

1

Arf GTPases and their effectors: assembling multivalent membrane-binding platforms

www.sciencedirect.com/science/article/abs/pii/S0959440X14001286?via%3Dihub

Arf6

Oct 8, 2023

33

Endolysosomal degradation of Tau and its role in glucocorticoid‐driven hippocampal malfunction

www.embopress.org/doi/full/10.15252/embj.201899084

Oct 8, 2023

42

Fluorescent Proteins 101: Fluorescent Protein Timers

blog.addgene.org/monitoring-molecular-age-with-fluorescent-protein-timers

Research tool

Oct 4, 2023

11

ガヤの日記

ikegaya.jp/diary/2003_10.htm

Oct 4, 2023

11

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

www.sciencedirect.com/science/article/pii/S0021925820308127

ESCRT
tau

Oct 3, 2023

1

Spatial atlas of the mouse central nervous system at molecular resolution - Nature

www.nature.com/articles/s41586-023-06569-5

nature

Oct 2, 2023

11

The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C

www.science.org/doi/10.1126/scitranslmed.abg2919?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

CD22

Oct 1, 2023

66

Glycinergic transmission in the mammalian retina

www.frontiersin.org/articles/10.3389/neuro.02.006.2009/full

GLRA1

Oct 1, 2023

11

Associations of plasma soluble CD22 levels with brain amyloid burden and cognitive decline in Alzheimer’s disease

www.science.org/doi/full/10.1126/sciadv.abm5667?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

CD22

Oct 1, 2023

52

Mechanism of gating and partial agonist action in the glycine receptor

www.sciencedirect.com/science/article/pii/S0092867421000696?via%3Dihub

Oct 1, 2023

33