genken

genken

@genken

Hibernation/Hypothalamus/Sympathetic Neuron/PostDoc/movies

Joined Jan 19, 2023

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Distinct tau folds initiate templated seeding and alter the post-translational modification profile

academic.oup.com/brain/advance-article/doi/10.1093/brain/awad272/7240187?login=true

alzheimer disease
tau phosphorylation
tau structure
tau

Nov 29, 2023

86

FEBS Press

febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.13657

tau
tau structure
alzheimer disease

Nov 29, 2023

11

CARD9 attenuates Aβ pathology and modifies microglial responses in an Alzheimer’s disease mouse model | Proceedings of the National Academy of Sciences

www.pnas.org/doi/full/10.1073/pnas.2303760120

CD22

Nov 23, 2023

33

PTEN deficiency exposes a requirement for an ARF GTPase module for integrin‐dependent invasion in ovarian cancer

www.embopress.org/doi/full/10.15252/embj.2023113987

積読
Arf6

Nov 22, 2023

11

The ARF GTPase regulatory network in collective invasion and metastasis

portlandpress.com/biochemsoctrans/article/51/4/1559/233421/The-ARF-GTPase-regulatory-network-in-collective

Arf6

Nov 22, 2023

54

Identification of phosphorylated tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission

onlinelibrary.wiley.com/doi/10.1111/jnc.15796

tau
Arf6

Nov 22, 2023

22

シングルセル解析③:ダブレット推定手法について - Aurora blog

auroratummy.hatenablog.com/entry/2020/10/28/072113

scRNAseq

Nov 21, 2023

11

Hygromycin B Gold | Selection Antibiotic | InvivoGen

www.invivogen.com/hygromycin

Research tool

Nov 21, 2023

1

Hygromycin B Frequently Asked Questions

astralscientific.com.au/blogs/news/hygromycin-b-frequently-asked-questions

Research tool

Nov 21, 2023

2

細胞夜話 第11回番外編:LBの塩濃度 - バイオダイレクトメール vol.48

www.cytivalifesciences.co.jp/newsletter/biodirect_mail/cell_story/47_ext.html

Research tool

Nov 21, 2023

21

Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease - Nature Neuroscience

www.nature.com/articles/s41593-022-01251-x

Nov 20, 2023

1

染色体に取り込まれずに遺伝子を持続的に発現できるベクター(エピソーマルベクター) | Enhanced Episomal Vector (EEV) | フナコシ

www.funakoshi.co.jp/contents/63198

Research tool

Nov 19, 2023

1

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading - Molecular Psychiatry

www.nature.com/articles/s41380-020-0738-0

tau secretion
tau

Nov 18, 2023

11

ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis | Journal of Cell Biology | Rockefeller University Press

rupress.org/jcb/article/162/4/647/33350/ARF6-regulates-a-plasma-membrane-pool-of

Arf6

Nov 18, 2023

1

Role of ADP-ribosylation Factor 6 (ARF6) in Gastric Acid Secretion

www.sciencedirect.com/science/article/pii/S0021925820834590

Arf6

Nov 18, 2023

55

Coupling actin and membrane dynamics during calcium-regulated exocytosis: a role for Rho and ARF GTPases

www.sciencedirect.com/science/article/pii/S0167488904002460

Nov 6, 2023

1

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle - Nature Communications

www.nature.com/articles/s41467-020-14893-x

Arf6

Nov 5, 2023

11

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

www.mdpi.com/1422-0067/21/7/2576

lysosome
exocytosis

Nov 5, 2023

11

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation - PubMed

pubmed.ncbi.nlm.nih.gov/9663393/

Nov 5, 2023

11

A role for phospholipase D1 in neurotransmitter release - PubMed

pubmed.ncbi.nlm.nih.gov/11752468/

Arf6

Nov 5, 2023

11

Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network - PubMed

pubmed.ncbi.nlm.nih.gov/9245781/

Arf6

Nov 5, 2023

11

ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate | Proceedings of the National Academy of Sciences

www.pnas.org/doi/full/10.1073/pnas.2232129100

Arf6

Nov 5, 2023

11

Class II Arfs require a brefeldin-A-sensitive factor for Golgi association

www.sciencedirect.com/science/article/abs/pii/S0006291X20313784

Nov 5, 2023

1

非アポトーシス細胞死を研究する | アブカム

www.abcam.co.jp/cancer/studying-non-apoptotic-cell-death

JC

Nov 2, 2023

11

MLKL ~ネクロトーシスのキープレーヤー | アブカム

www.abcam.co.jp/primary-antibodies/antibody-focus-mlkl-1

JC

Nov 2, 2023

31

Soluble CD22 as a tumor marker for hairy cell leukemia

ashpublications.org/blood/article/112/6/2272/24868/Soluble-CD22-as-a-tumor-marker-for-hairy-cell

CD22

Oct 29, 2023

11

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine - Nature

www.nature.com/articles/nature14972

GLRA1

Oct 23, 2023

1

Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease - Genome Medicine

genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01136-5

Oct 21, 2023

1

Gene therapy: progress and predictions - PubMed

pubmed.ncbi.nlm.nih.gov/26702034/

Oct 13, 2023

1

Arf GTPases and their effectors: assembling multivalent membrane-binding platforms

www.sciencedirect.com/science/article/abs/pii/S0959440X14001286?via%3Dihub

Arf6

Oct 8, 2023

33

Endolysosomal degradation of Tau and its role in glucocorticoid‐driven hippocampal malfunction

www.embopress.org/doi/full/10.15252/embj.201899084

Oct 8, 2023

42

Fluorescent Proteins 101: Fluorescent Protein Timers

blog.addgene.org/monitoring-molecular-age-with-fluorescent-protein-timers

Research tool

Oct 4, 2023

11

ガヤの日記

ikegaya.jp/diary/2003_10.htm

Oct 4, 2023

11

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

www.sciencedirect.com/science/article/pii/S0021925820308127

ESCRT
tau

Oct 3, 2023

1

Spatial atlas of the mouse central nervous system at molecular resolution - Nature

www.nature.com/articles/s41586-023-06569-5

nature

Oct 2, 2023

11

The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C

www.science.org/doi/10.1126/scitranslmed.abg2919?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

CD22

Oct 1, 2023

66

Glycinergic transmission in the mammalian retina

www.frontiersin.org/articles/10.3389/neuro.02.006.2009/full

GLRA1

Oct 1, 2023

11

Associations of plasma soluble CD22 levels with brain amyloid burden and cognitive decline in Alzheimer’s disease

www.science.org/doi/full/10.1126/sciadv.abm5667?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

CD22

Oct 1, 2023

52

Mechanism of gating and partial agonist action in the glycine receptor

www.sciencedirect.com/science/article/pii/S0092867421000696?via%3Dihub

Oct 1, 2023

33

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

www.biorxiv.org/content/10.1101/2023.06.16.545386v2.full

Sep 22, 2023

3

CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity - Nature Immunology

www.nature.com/articles/ni1072

CD22

Sep 19, 2023

2

Internalization of the Lymphocytic Surface Protein CD22 Is Controlled by a Novel Membrane Proximal Cytoplasmic Motif *

www.jbc.org/article/S0021-9258%2819%2959533-3/fulltext

CD22

Sep 19, 2023

1

CD22: an inhibitory enigma

onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2007.02752.x

CD22

Sep 19, 2023

136

The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound | Journal of Experimental Medicine | Rockefeller University Press

rupress.org/jem/article/195/9/1207/39599/The-Ligand-binding-Domain-of-CD22-Is-Needed-for

CD22

Sep 19, 2023

11

Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound - Nature Metabolism

www.nature.com/articles/s42255-023-00804-z

hibernation
積読

Sep 19, 2023

2

The chloride anion as a signalling effector

onlinelibrary.wiley.com/doi/10.1111/brv.12536

Cl ion

Sep 19, 2023

44

Simultaneous intracellular chloride and pH measurements using a GFP-based sensor - Nature Methods

www.nature.com/articles/nmeth.1471

Cl ion

Sep 18, 2023

2

A Superfolder Green Fluorescent Protein-Based Biosensor Allows Monitoring of Chloride in the Endoplasmic Reticulum

pubs.acs.org/doi/10.1021/acssensors.2c00626

Cl ion

Sep 18, 2023

21

Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo | Proceedings of the National Academy of Sciences

www.pnas.org/doi/abs/10.1073/pnas.1702861114?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Cl ion

Sep 18, 2023

1