genken

genken

@genken

Hibernation/Hypothalamus/Sympathetic Neuron/PostDoc/movies

Joined Jan 19, 2023

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Integrative in situ mapping of single-cell transcriptional states and tissue histopathology in a mouse model of Alzheimer’s disease - Nature Neuroscience

www.nature.com/articles/s41593-022-01251-x

Nov 20, 2023

1

染色体に取り込まれずに遺伝子を持続的に発現できるベクター(エピソーマルベクター) | Enhanced Episomal Vector (EEV) | フナコシ

www.funakoshi.co.jp/contents/63198

Research tool

Nov 19, 2023

1

TFEB regulates lysosomal exocytosis of tau and its loss of function exacerbates tau pathology and spreading - Molecular Psychiatry

www.nature.com/articles/s41380-020-0738-0

tau secretion
tau

Nov 18, 2023

11

ARF6 regulates a plasma membrane pool of phosphatidylinositol(4,5)bisphosphate required for regulated exocytosis | Journal of Cell Biology | Rockefeller University Press

rupress.org/jcb/article/162/4/647/33350/ARF6-regulates-a-plasma-membrane-pool-of

Arf6

Nov 18, 2023

1

Role of ADP-ribosylation Factor 6 (ARF6) in Gastric Acid Secretion

www.sciencedirect.com/science/article/pii/S0021925820834590

Arf6

Nov 18, 2023

55

Coupling actin and membrane dynamics during calcium-regulated exocytosis: a role for Rho and ARF GTPases

www.sciencedirect.com/science/article/pii/S0167488904002460

Nov 6, 2023

1

NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle - Nature Communications

www.nature.com/articles/s41467-020-14893-x

Arf6

Nov 5, 2023

11

Lysosomal Exocytosis, Exosome Release and Secretory Autophagy: The Autophagic- and Endo-Lysosomal Systems Go Extracellular

www.mdpi.com/1422-0067/21/7/2576

lysosome
exocytosis

Nov 5, 2023

11

Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation - PubMed

pubmed.ncbi.nlm.nih.gov/9663393/

Nov 5, 2023

11

A role for phospholipase D1 in neurotransmitter release - PubMed

pubmed.ncbi.nlm.nih.gov/11752468/

Arf6

Nov 5, 2023

11

Phospholipase D stimulates release of nascent secretory vesicles from the trans-Golgi network - PubMed

pubmed.ncbi.nlm.nih.gov/9245781/

Arf6

Nov 5, 2023

11

ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate | Proceedings of the National Academy of Sciences

www.pnas.org/doi/full/10.1073/pnas.2232129100

Arf6

Nov 5, 2023

11

Class II Arfs require a brefeldin-A-sensitive factor for Golgi association

www.sciencedirect.com/science/article/abs/pii/S0006291X20313784

Nov 5, 2023

1

非アポトーシス細胞死を研究する | アブカム

www.abcam.co.jp/cancer/studying-non-apoptotic-cell-death

JC

Nov 2, 2023

11

MLKL ~ネクロトーシスのキープレーヤー | アブカム

www.abcam.co.jp/primary-antibodies/antibody-focus-mlkl-1

JC

Nov 2, 2023

31

Soluble CD22 as a tumor marker for hairy cell leukemia

ashpublications.org/blood/article/112/6/2272/24868/Soluble-CD22-as-a-tumor-marker-for-hairy-cell

CD22

Oct 29, 2023

11

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine - Nature

www.nature.com/articles/nature14972

GLRA1

Oct 23, 2023

1

Cell type-specific changes identified by single-cell transcriptomics in Alzheimer’s disease - Genome Medicine

genomemedicine.biomedcentral.com/articles/10.1186/s13073-022-01136-5

Oct 21, 2023

1

Gene therapy: progress and predictions - PubMed

pubmed.ncbi.nlm.nih.gov/26702034/

Oct 13, 2023

1

Arf GTPases and their effectors: assembling multivalent membrane-binding platforms

www.sciencedirect.com/science/article/abs/pii/S0959440X14001286?via%3Dihub

Arf6

Oct 8, 2023

33

Endolysosomal degradation of Tau and its role in glucocorticoid‐driven hippocampal malfunction

www.embopress.org/doi/full/10.15252/embj.201899084

Oct 8, 2023

42

Fluorescent Proteins 101: Fluorescent Protein Timers

blog.addgene.org/monitoring-molecular-age-with-fluorescent-protein-timers

Research tool

Oct 4, 2023

11

ガヤの日記

ikegaya.jp/diary/2003_10.htm

Oct 4, 2023

11

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

www.sciencedirect.com/science/article/pii/S0021925820308127

ESCRT
tau

Oct 3, 2023

1

Spatial atlas of the mouse central nervous system at molecular resolution - Nature

www.nature.com/articles/s41586-023-06569-5

nature

Oct 2, 2023

11

The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C

www.science.org/doi/10.1126/scitranslmed.abg2919?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

CD22

Oct 1, 2023

66

Glycinergic transmission in the mammalian retina

www.frontiersin.org/articles/10.3389/neuro.02.006.2009/full

GLRA1

Oct 1, 2023

11

Associations of plasma soluble CD22 levels with brain amyloid burden and cognitive decline in Alzheimer’s disease

www.science.org/doi/full/10.1126/sciadv.abm5667?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

CD22

Oct 1, 2023

52

Mechanism of gating and partial agonist action in the glycine receptor

www.sciencedirect.com/science/article/pii/S0092867421000696?via%3Dihub

Oct 1, 2023

33

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

www.biorxiv.org/content/10.1101/2023.06.16.545386v2.full

Sep 22, 2023

3

CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity - Nature Immunology

www.nature.com/articles/ni1072

CD22

Sep 19, 2023

2

Internalization of the Lymphocytic Surface Protein CD22 Is Controlled by a Novel Membrane Proximal Cytoplasmic Motif *

www.jbc.org/article/S0021-9258%2819%2959533-3/fulltext

CD22

Sep 19, 2023

1

CD22: an inhibitory enigma

onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2007.02752.x

CD22

Sep 19, 2023

136

The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound | Journal of Experimental Medicine | Rockefeller University Press

rupress.org/jem/article/195/9/1207/39599/The-Ligand-binding-Domain-of-CD22-Is-Needed-for

CD22

Sep 19, 2023

11

Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound - Nature Metabolism

www.nature.com/articles/s42255-023-00804-z

hibernation
積読

Sep 19, 2023

2

The chloride anion as a signalling effector

onlinelibrary.wiley.com/doi/10.1111/brv.12536

Cl ion

Sep 19, 2023

44

Simultaneous intracellular chloride and pH measurements using a GFP-based sensor - Nature Methods

www.nature.com/articles/nmeth.1471

Cl ion

Sep 18, 2023

2

A Superfolder Green Fluorescent Protein-Based Biosensor Allows Monitoring of Chloride in the Endoplasmic Reticulum

pubs.acs.org/doi/10.1021/acssensors.2c00626

Cl ion

Sep 18, 2023

21

Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo | Proceedings of the National Academy of Sciences

www.pnas.org/doi/abs/10.1073/pnas.1702861114?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Cl ion

Sep 18, 2023

1

Impaired Glycine Receptor Trafficking in Neurological Diseases

www.frontiersin.org/articles/10.3389/fnmol.2018.00291/full

GLRA1

Sep 18, 2023

Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases

www.frontiersin.org/articles/10.3389/fimmu.2021.762564/full

GLRA1

Sep 17, 2023

22

Modulators of the Inhibitory Glycine Receptor

pubs.acs.org/doi/10.1021/acschemneuro.0c00054

GLRA1

Sep 17, 2023

55

The impact of human hyperekplexia mutations on glycine receptor structure and function - Molecular Brain

molecularbrain.biomedcentral.com/articles/10.1186/1756-6606-7-2

GLRA1

Sep 16, 2023

42

The genetics of hyperekplexia: more than startle!

www.cell.com/trends/genetics/fulltext/S0168-9525%2808%2900200-X?code=cell-site

GLRA1

Sep 16, 2023

43

Native glycine receptor subtypes and their physiological roles

www.sciencedirect.com/science/article/pii/S0028390808003171?via%3Dihub

Sep 16, 2023

1413

DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon | Journal of Cell Biology | Rockefeller University Press

rupress.org/jcb/article/216/11/3625/38999/DC2-and-KCP2-mediate-the-interaction-between-the

KCP2

Sep 12, 2023

1

Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase

journals.biologists.com/jcs/article/125/1/220/32259/Keratinocyte-associated-protein-2-is-a-bona-fide

KCP2

Sep 12, 2023

1

A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells - Nature Communications

www.nature.com/articles/s41467-021-23274-x

読み会

Sep 1, 2023

2

LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits - Nature Aging

www.nature.com/articles/s43587-023-00464-4

読み会

Aug 25, 2023

33