genken

genken

@genken

Hibernation/Hypothalamus/Sympathetic Neuron/PostDoc/movies

Joined Jan 19, 2023

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Fluorescent Proteins 101: Fluorescent Protein Timers

blog.addgene.org/monitoring-molecular-age-with-fluorescent-protein-timers

Research tool

Oct 4, 2023

11

ガヤの日記

ikegaya.jp/diary/2003_10.htm

Oct 4, 2023

11

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

www.sciencedirect.com/science/article/pii/S0021925820308127

ESCRT
tau

Oct 3, 2023

1

Spatial atlas of the mouse central nervous system at molecular resolution - Nature

www.nature.com/articles/s41586-023-06569-5

nature

Oct 2, 2023

11

The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C

www.science.org/doi/10.1126/scitranslmed.abg2919?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

CD22

Oct 1, 2023

66

Glycinergic transmission in the mammalian retina

www.frontiersin.org/articles/10.3389/neuro.02.006.2009/full

GLRA1

Oct 1, 2023

11

Associations of plasma soluble CD22 levels with brain amyloid burden and cognitive decline in Alzheimer’s disease

www.science.org/doi/full/10.1126/sciadv.abm5667?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

CD22

Oct 1, 2023

52

Mechanism of gating and partial agonist action in the glycine receptor

www.sciencedirect.com/science/article/pii/S0092867421000696?via%3Dihub

Oct 1, 2023

33

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

www.biorxiv.org/content/10.1101/2023.06.16.545386v2.full

Sep 22, 2023

3

CD22 attenuates calcium signaling by potentiating plasma membrane calcium-ATPase activity - Nature Immunology

www.nature.com/articles/ni1072

CD22

Sep 19, 2023

2

Internalization of the Lymphocytic Surface Protein CD22 Is Controlled by a Novel Membrane Proximal Cytoplasmic Motif *

www.jbc.org/article/S0021-9258%2819%2959533-3/fulltext

CD22

Sep 19, 2023

1

CD22: an inhibitory enigma

onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2007.02752.x

CD22

Sep 19, 2023

136

The Ligand-binding Domain of CD22 Is Needed for Inhibition of the B Cell Receptor Signal, as Demonstrated by a Novel Human CD22-specific Inhibitor Compound | Journal of Experimental Medicine | Rockefeller University Press

rupress.org/jem/article/195/9/1207/39599/The-Ligand-binding-Domain-of-CD22-Is-Needed-for

CD22

Sep 19, 2023

11

Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound - Nature Metabolism

www.nature.com/articles/s42255-023-00804-z

hibernation
積読

Sep 19, 2023

2

The chloride anion as a signalling effector

onlinelibrary.wiley.com/doi/10.1111/brv.12536

Cl ion

Sep 19, 2023

44

Simultaneous intracellular chloride and pH measurements using a GFP-based sensor - Nature Methods

www.nature.com/articles/nmeth.1471

Cl ion

Sep 18, 2023

2

A Superfolder Green Fluorescent Protein-Based Biosensor Allows Monitoring of Chloride in the Endoplasmic Reticulum

pubs.acs.org/doi/10.1021/acssensors.2c00626

Cl ion

Sep 18, 2023

21

Simultaneous two-photon imaging of intracellular chloride concentration and pH in mouse pyramidal neurons in vivo | Proceedings of the National Academy of Sciences

www.pnas.org/doi/abs/10.1073/pnas.1702861114?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Cl ion

Sep 18, 2023

1

Impaired Glycine Receptor Trafficking in Neurological Diseases

www.frontiersin.org/articles/10.3389/fnmol.2018.00291/full

GLRA1

Sep 18, 2023

Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases

www.frontiersin.org/articles/10.3389/fimmu.2021.762564/full

GLRA1

Sep 17, 2023

22

Modulators of the Inhibitory Glycine Receptor

pubs.acs.org/doi/10.1021/acschemneuro.0c00054

GLRA1

Sep 17, 2023

55

The impact of human hyperekplexia mutations on glycine receptor structure and function - Molecular Brain

molecularbrain.biomedcentral.com/articles/10.1186/1756-6606-7-2

GLRA1

Sep 16, 2023

42

The genetics of hyperekplexia: more than startle!

www.cell.com/trends/genetics/fulltext/S0168-9525%2808%2900200-X?code=cell-site

GLRA1

Sep 16, 2023

43

Native glycine receptor subtypes and their physiological roles

www.sciencedirect.com/science/article/pii/S0028390808003171?via%3Dihub

Sep 16, 2023

1413

DC2 and KCP2 mediate the interaction between the oligosaccharyltransferase and the ER translocon | Journal of Cell Biology | Rockefeller University Press

rupress.org/jcb/article/216/11/3625/38999/DC2-and-KCP2-mediate-the-interaction-between-the

KCP2

Sep 12, 2023

1

Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase

journals.biologists.com/jcs/article/125/1/220/32259/Keratinocyte-associated-protein-2-is-a-bona-fide

KCP2

Sep 12, 2023

1

A human antibody selective for transthyretin amyloid removes cardiac amyloid through phagocytic immune cells - Nature Communications

www.nature.com/articles/s41467-021-23274-x

読み会

Sep 1, 2023

2

LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits - Nature Aging

www.nature.com/articles/s43587-023-00464-4

読み会

Aug 25, 2023

33

Formation of Disulfide Bridges Drives Oligomerization, Membrane Pore Formation, and Translocation of Fibroblast Growth Factor 2 to Cell Surfaces

www.sciencedirect.com/science/article/pii/S0021925819819865

FGF2
tau secretion

Aug 21, 2023

11

Distinct spatial maps and multiple object codes in the lateral entorhinal cortex

www.sciencedirect.com/science/article/pii/S0896627323004798

Aug 17, 2023

88

www.cell.com/neuron/pdf/S0896-6273(23)00479-8.pdf

JC

Aug 17, 2023

WNT5A - Protein Wnt-5a - Homo sapiens (Human) | UniProtKB | UniProt

www.uniprot.org/uniprotkb/P41221/entry

Aug 10, 2023

TRIM11 protects against tauopathies and is down-regulated in Alzheimer’s disease

www.science.org/doi/10.1126/science.add6696

JC
tau

Aug 3, 2023

1

Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist | Proceedings of the National Academy of Sciences

www.pnas.org/doi/10.1073/pnas.2014879117

JC

Jul 27, 2023

1

Immunotherapy targeting plasma ASM is protective in a mouse model of Alzheimer’s disease - Nature Communications

www.nature.com/articles/s41467-023-37316-z

読み会
alzheimer disease

Jul 21, 2023

1

Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area

www.sciencedirect.com/science/article/pii/S0896627319303927

積読
preoptic area
thermoregulation

Jul 20, 2023

1

Warm-Sensitive Neurons that Control Body Temperature

www.cell.com/fulltext/S0092-8674(16)31079-0

preoptic area
thermoregulation
hypothalamus

Jul 19, 2023

1

Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to N6‐cyclohexyladenosine‐induced hibernation in the Arctic ground squirrel (Urocitellus parryii)

onlinelibrary.wiley.com/doi/10.1111/jnc.14814

hibernation
cFos

Jul 19, 2023

97

Clock Gene Expression in the Suprachiasmatic Nucleus of Hibernating Arctic Ground Squirrels - Tomoko Ikeno, Cory T. Williams, C. Loren Buck, Brian M. Barnes, Lily Yan, 2017

journals.sagepub.com/doi/10.1177/0748730417702246?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

hibernation
SCN
cFos

Jul 19, 2023

54

Neuronal Activity in the Hibernating Brain

www.frontiersin.org/articles/10.3389/fnana.2019.00071/full

積読
hibernation

Jul 18, 2023

1311

Gene Expression in the Brain across the Hibernation Cycle

www.jneurosci.org/content/19/10/3781/tab-figures-data

hibernation

Jul 18, 2023

Berlin-Hamster-Single-Cell-Consortium · GitHub

github.com/Berlin-Hamster-Single-Cell-Consortium

hamster
scRNAseq

Jul 18, 2023

11

Spatial and temporal activation of brain regions in hibernation: c‐fos expression during the hibernation bout in thirteen‐lined ground squirrel

onlinelibrary.wiley.com/doi/10.1002/cne.21507

hibernation
preoptic area
cFos

Jul 18, 2023

C-fos mRNA increases in the ground squirrel suprachiasmatic nucleus during arousal from hibernation

www.sciencedirect.com/science/article/pii/0304394094907234?via%3Dihub

hibernation
cFos

Jul 18, 2023

11

Hypothalamic orexinergic neuron changes during the hibernation of the Syrian hamster

www.frontiersin.org/articles/10.3389/fnana.2022.993421/full

hibernation
cFos

Jul 18, 2023

98

Gene Expression in the Brain across the Hibernation Cycle

www.jneurosci.org/content/19/10/3781.long

hibernation
cFos

Jul 18, 2023

33

Tau Propagation Surprise: It Might Travel Retrogradely | ALZFORUM

www.alzforum.org/news/research-news/tau-propagation-surprise-it-might-travel-retrogradely

積読
tau
Alzforum

Jul 17, 2023

33

Parallel Accelerated Evolution in Distant Hibernators Reveals Candidate Cis Elements and Genetic Circuits Regulating Mammalian Obesity

www.cell.com/cell-reports/fulltext/S2211-1247(19)31435-4

hibernation
冬眠研究の意義

Jul 12, 2023

1

How hibernation and hypothermia help to improve anticoagulant control

www.tandfonline.com/doi/full/10.4161/23328940.2014.967595

hibernation
冬眠研究の意義

Jul 12, 2023

1