genken

genken

@genken

Hibernation/Hypothalamus/Sympathetic Neuron/PostDoc/movies

Joined Jan 19, 2023

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7

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721

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Sleep restores an optimal computational regime in cortical networks - Nature Neuroscience

www.nature.com/articles/s41593-023-01536-9

JC

Jan 25, 2024

11

ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells - Nature Communications

www.nature.com/articles/s41467-023-44319-3

JC
CART
immunology
読み会

Jan 25, 2024

1

Evolutionary trade-offs in dormancy phenology

www.biorxiv.org/content/10.1101/2023.07.20.549898v4

hibernation

Jan 24, 2024

11

Cell death

www.cell.com/cell/fulltext/S0092-8674(23)01332-6

積読

Jan 24, 2024

1

Making the connection: How membrane contact sites have changed our view of organelle biology

www.cell.com/cell/fulltext/S0092-8674(23)01328-4

積読

Jan 24, 2024

1

A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice - Nature Neuroscience

www.nature.com/articles/s41593-023-01504-3

neuronal circuit

Jan 24, 2024

1

Nano-CUT&Tag for multimodal chromatin profiling at single-cell resolution - Nature Protocols

www.nature.com/articles/s41596-023-00932-6

Research tool

Jan 24, 2024

11

Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory | Proceedings of the National Academy of Sciences

www.pnas.org/doi/10.1073/pnas.2312752120

memory
synaptic plasticity

Jan 24, 2024

11

Social anxiety disorder-associated gut microbiota increases social fear | Proceedings of the National Academy of Sciences

www.pnas.org/doi/10.1073/pnas.2308706120

hypothalamus
preoptic area
oxytocin
microbiome

Jan 24, 2024

11

Bacteria stitch exotic building blocks into novel proteins

www.science.org/content/article/bacteria-stitch-exotic-building-blocks-novel-proteins

science

Jan 24, 2024

11

Arf6 as a therapeutic target: Structure, mechanism, and inhibitors

www.sciencedirect.com/science/article/pii/S2211383523002113

Arf6
inihibitor

Jan 24, 2024

9

Movement and space use patterns of black bears in relation to migratory caribou in Northern Quebec and Labrador

corpus.ulaval.ca/entities/publication/80f2a294-ad35-4f32-86a0-fa3ebdce7b4d

hibernation
bear

Jan 23, 2024

1

Parallel genetic excisions of the cardiac troponin I N-terminal extension in tachycardic mammals

www.biorxiv.org/content/10.1101/2023.05.19.541292v2

hibernation
muscle

Jan 23, 2024

1

Physiological properties of the innervated and denervated neuromuscular junction of hibernating and nonhibernating ground squirrels

www.sciencedirect.com/science/article/pii/0014488678900614?via%3Dihub

Jan 23, 2024

21

Primate preoptic neurons drive hypothermia and cold defense

www.cell.com/the-innovation/fulltext/S2666-6758(22)00154-0

hibernation
torpor
hypothalamus
preoptic area

Jan 23, 2024

11

Can mechanistic constraints on recombination reestablishment explain the long-term maintenance of degenerate sex chromosomes?

www.biorxiv.org/content/10.1101/2023.02.17.528909v4

biorxiv

Jan 23, 2024

1

Local translation is engaged to sustain circuit integrity in severed preserved axonal and synaptic projections

www.biorxiv.org/content/10.1101/2023.08.18.553870v2

hibernation
biorxiv
axon degeneration

Jan 23, 2024

1

Co-roosting relationships are consistent across years in a bat maternity group - Scientific Reports

www.nature.com/articles/s41598-023-50191-4

bat

Jan 23, 2024

1

Phospholipase D and phosphatidic acid in the biogenesis and cargo loading of extracellular vesicles: Thematic Review Series: Exosomes and Microvesicles: Lipids as Key Components of their Biogenesis and Functions

www.sciencedirect.com/science/article/pii/S0022227520335252

Arf6-PLD

Jan 20, 2024

1

Localization and regulation of phospholipase D2 by ARF6

onlinelibrary.wiley.com/doi/abs/10.1002/jcb.20351

Arf6
Arf6-PLD

Jan 20, 2024

1

Regulation of Phospholipase D by Arf6 during FcγR-Mediated Phagocytosis

journals.aai.org/jimmunol/article/202/10/2971/862/Regulation-of-Phospholipase-D-by-Arf6-during-Fc-R

Arf6
Arf6-PLD

Jan 20, 2024

11

An Effector Domain Mutant of Arf6 Implicates Phospholipase D in Endosomal Membrane Recycling

www.molbiolcell.org/doi/full/10.1091/mbc.e05-06-0523

Arf6-PLD
Arf6

Jan 20, 2024

22

ARF GTPases and their GEFs and GAPs: concepts and challenges

www.molbiolcell.org/doi/full/10.1091/mbc.E18-12-0820

Arf6

Jan 20, 2024

1

Physiological functions of the small GTPase Arf6 in the nervous system

www.tandfonline.com/doi/full/10.1080/21541248.2015.1043041

Arf6

Jan 20, 2024

22

Arf GTPases and their effectors: assembling multivalent membrane-binding platforms

www-sciencedirect-com.utokyo.idm.oclc.org/science/article/pii/S0959440X14001286?via%3Dihub

Jan 20, 2024

53

Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-β-associated pathology in APP/PS1 mouse model of Alzheimer’s disease

www.ncbi.nlm.nih.gov/pmc/articles/PMC10725492/

読み会
Research tool
疑問

Jan 19, 2024

11

Pathogenic LRRK2 compromises the subcellular distribution of lysosomes in a Rab12‐RILPL1‐dependent manner

faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202200780RR

IP
Research tool

Jan 19, 2024

11

Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D

rupress.org/jcb/article-standard/196/4/483/36778/Arf6-promotes-autophagosome-formation-via-effects

Arf6

Jan 18, 2024

11

Regulation of PIP5K activity by Arf6 and its physiological significance

onlinelibrary.wiley.com/doi/10.1002/jcp.22482

Arf6

Jan 18, 2024

3

Activation mechanisms of PIP5K isozymes by the small GTPase ARF6

www.sciencedirect.com/science/article/pii/S0065257109000909?via%3Dihub

Arf6

Jan 18, 2024

3

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I.

www.ncbi.nlm.nih.gov/pmc/articles/PMC1220346/

Arf6
N48RI

Jan 17, 2024

11

Calcium-regulated exocytosis of dense-core vesicles requires the activation of ADP-ribosylation factor (ARF)6 by ARF nucleotide binding site opener at the plasma membrane | Journal of Cell Biology | Rockefeller University Press

rupress.org/jcb/article/159/1/79/32968/Calcium-regulated-exocytosis-of-dense-core

Jan 17, 2024

44

Real-time visualization of structural dynamics of synapses in live cells in vivo - Nature Methods

www.nature.com/articles/s41592-023-02122-4

Research tool
積読
synapse tracer

Jan 16, 2024

21

Long-term labeling and imaging of synaptically connected neuronal networks in vivo using double-deletion-mutant rabies viruses - Nature Neuroscience

www.nature.com/articles/s41593-023-01545-8

積読
Research tool
synapse tracer

Jan 16, 2024

43

Meningeal interleukin-17-producing T cells mediate cognitive impairment in a mouse model of salt-sensitive hypertension - Nature Neuroscience

www.nature.com/articles/s41593-023-01497-z

immunology

Jan 16, 2024

11

Decoding the language of immunity

www.science.org/doi/10.1126/science.adn1067

immunology
basic research

Jan 16, 2024

55

Spatial IMA1 regulation restricts root iron acquisition on MAMP perception - Nature

www.nature.com/articles/s41586-023-06891-y

Jan 16, 2024

22

Causes and consequences of pre-hibernation body mass in golden-mantled ground squirrels (Callospermophilus lateralis)

academic.oup.com/jmammal/advance-article/doi/10.1093/jmammal/gyad131/7517779?login=true

hibernation

Jan 16, 2024

98

Mitochondrial Targeting against Alzheimer’s Disease: Lessons from Hibernation

www.mdpi.com/2073-4409/13/1/12

冬眠研究の意義

Jan 13, 2024

1

Torpor: A whole-brain view of the underlying neural network

www.cell.com/current-biology/pdf/S0960-9822(23)01638-X.pdf

積読
hibernation
torpor

Jan 13, 2024

1

prof. dr. R.H. (Rob) Henning

www.rug.nl/staff/r.h.henning/

hibernation
冬眠競合ラボ

Jan 11, 2024

1

Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation

www.frontiersin.org/articles/10.3389/fphys.2023.1129278/full

Jan 11, 2024

1

Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer’s disease - Scientific Reports

www.nature.com/articles/s41598-021-94992-x

冬眠研究の意義
積読
hibernation
alzheimer disease

Jan 11, 2024

1

Proteome census upon nutrient stress reveals Golgiphagy membrane receptors - Nature

www.nature.com/articles/s41586-023-06657-6

読み会

Jan 10, 2024

165

Lipid-anchored proteasomes control membrane protein homeostasis

www.science.org/doi/10.1126/sciadv.adj4605

Jan 9, 2024

11

Synapse-specific burst coding sustained by local axonal translation

www.cell.com/neuron/fulltext/S0896-6273(23)00767-5

積読
Neuron

Jan 9, 2024

11

Control and coding of pupil size by hypothalamic orexin neurons - Nature Neuroscience

www.nature.com/articles/s41593-023-01365-w

積読
sleep
hypothalamus
Nat Neurosci

Jan 9, 2024

11

TFEB–vacuolar ATPase signaling regulates lysosomal function and microglial activation in tauopathy - Nature Neuroscience

www.nature.com/articles/s41593-023-01494-2

積読
lysosome
tau

Jan 9, 2024

1

Esr1+ hypothalamic-habenula neurons shape aversive states - Nature Neuroscience

www.nature.com/articles/s41593-023-01367-8

hypothalamus
積読
scRNAseq

Jan 9, 2024

11

The medial preoptic area mediates depressive-like behaviors induced by ovarian hormone withdrawal through distinct GABAergic projections - Nature Neuroscience

www.nature.com/articles/s41593-023-01397-2

preoptic area
積読
hypothalamus

Jan 9, 2024

11