genken

genken

@genken

Hibernation/Hypothalamus/Sympathetic Neuron/PostDoc/movies

Joined Jan 19, 2023

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Single nucleus RNA-sequencing defines unexpected diversity of cholinergic neuron types in the adult mouse spinal cord - Nature Communications

www.nature.com/articles/s41467-021-22691-2

積読
spinal cord
scRNAseq

Feb 12, 2024

1

Seurat - Guided Clustering Tutorial

satijalab.org/seurat/archive/v3.2/pbmc3k_tutorial.html

Feb 12, 2024

1

Seuratを駆使する会 ① - ばいばいバイオ

www.kimoton.com/entry/2018/08/14/072409

R
scRNAseq

Feb 12, 2024

11

NGS(次世代シーケンス)における分子バーコード(UMI)の利用

yhamangs.com/molecular-barcode/

scRNAseq

Feb 10, 2024

11

Seurat - Guided Clustering Tutorial

satijalab.org/seurat/articles/pbmc3k_tutorial

Feb 9, 2024

1

Spatial transcriptomics in neuroscience - Experimental & Molecular Medicine

www.nature.com/articles/s12276-023-01093-y

Feb 8, 2024

55

実験医学別冊 最強のステップUPシリーズ:空間オミクス解析スタートアップ実践ガイド〜最新機器の特徴と目的に合った選び方、データ解析と応用例を学び、シングルセル解析の一歩その先へ!

www.yodosha.co.jp/yodobook/book/9784758122610/11.html

Feb 7, 2024

83

Single-neuron projectomes of mouse paraventricular hypothalamic nucleus oxytocin neurons reveal mutually exclusive projection patterns

www.cell.com/neuron/fulltext/S0896-6273(23)01010-3

Feb 7, 2024

158

脳科学における因果関係とは何か?|えぬ

note.com/baribio91/n/nad62653c2121

Feb 6, 2024

1

Causation in neuroscience: keeping mechanism meaningful - Nature Reviews Neuroscience

www.nature.com/articles/s41583-023-00778-7

積読
Research tool

Feb 6, 2024

1

Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region

www.science.org/doi/10.1126/science.aau5324?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Feb 5, 2024

54

HypoMap—a unified single-cell gene expression atlas of the murine hypothalamus - Nature Metabolism

www.nature.com/articles/s42255-022-00657-y

hypothalamus
scRNAseq
resource

Feb 4, 2024

1

The structural and functional complexity of the integrative hypothalamus

www.science.org/doi/10.1126/science.adh8488

science
hypothalamus

Feb 3, 2024

128

Clearance of β-amyloid and synapses by the optogenetic depolarization of microglia is complement selective

www.cell.com/neuron/fulltext/S0896-6273(23)00931-5

Neuron
alzheimer disease
読み会

Feb 2, 2024

1

Body temperature regulates glucose metabolism and torpid

www.biorxiv.org/content/10.1101/2024.01.29.577738v1.full.pdf+html

Feb 1, 2024

Body temperature regulates glucose metabolism and torpid

www.biorxiv.org/content/10.1101/2024.01.29.577738v1?ct=

積読
torpor
preoptic area
hypothalamus
qrfp

Feb 1, 2024

1

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

www.biorxiv.org/content/10.1101/2023.02.27.530270v3

冬眠研究の意義
低代謝

Jan 31, 2024

11

Nutrient Abundance Signals the Changing of the Seasons by Phosphorylating PER2

www.biorxiv.org/content/10.1101/2024.01.29.577255v1.full.pdf+html

Jan 31, 2024

Nutrient Abundance Signals the Changing of the Seasons by Phosphorylating PER2

www.biorxiv.org/content/10.1101/2024.01.29.577255v1

circadian rhythm
biorxiv

Jan 31, 2024

1

Amazon.co.jp: Dell S2722QC 27インチ 4K モニター (3年間無輝点交換保証/IPS非光沢/USB Type-C・HDMIx2/sRGB 99%/縦横回転・高さ調整/4ms/AMD FreeSync/スピーカー付) : パソコン・周辺機器

www.amazon.co.jp/dp/B09CGY99X5?tag=rviews02-22&linkCode=ogi&th=1

Jan 30, 2024

1

AgRP neurons encode circadian feeding time - Nature Neuroscience

www.nature.com/articles/s41593-023-01482-6

appetite
積読
AgRP
circadian rhythm
Nat Neurosci

Jan 25, 2024

1

Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus - Nature Neuroscience

www.nature.com/articles/s41593-023-01430-4

積読
sleep
preoptic area
hypothalamus
Nat Neurosci

Jan 25, 2024

1

Sleep restores an optimal computational regime in cortical networks - Nature Neuroscience

www.nature.com/articles/s41593-023-01536-9

JC

Jan 25, 2024

11

ANKS1A regulates LDL receptor-related protein 1 (LRP1)-mediated cerebrovascular clearance in brain endothelial cells - Nature Communications

www.nature.com/articles/s41467-023-44319-3

JC
CART
immunology
読み会

Jan 25, 2024

1

Evolutionary trade-offs in dormancy phenology

www.biorxiv.org/content/10.1101/2023.07.20.549898v4

hibernation

Jan 24, 2024

11

Cell death

www.cell.com/cell/fulltext/S0092-8674(23)01332-6

積読

Jan 24, 2024

1

Making the connection: How membrane contact sites have changed our view of organelle biology

www.cell.com/cell/fulltext/S0092-8674(23)01328-4

積読

Jan 24, 2024

1

A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice - Nature Neuroscience

www.nature.com/articles/s41593-023-01504-3

neuronal circuit

Jan 24, 2024

1

Nano-CUT&Tag for multimodal chromatin profiling at single-cell resolution - Nature Protocols

www.nature.com/articles/s41596-023-00932-6

Research tool

Jan 24, 2024

11

Synaptic plasticity at the dentate gyrus granule cell to somatostatin-expressing interneuron synapses supports object location memory | Proceedings of the National Academy of Sciences

www.pnas.org/doi/10.1073/pnas.2312752120

memory
synaptic plasticity

Jan 24, 2024

11

Social anxiety disorder-associated gut microbiota increases social fear | Proceedings of the National Academy of Sciences

www.pnas.org/doi/10.1073/pnas.2308706120

hypothalamus
preoptic area
oxytocin
microbiome

Jan 24, 2024

11

Bacteria stitch exotic building blocks into novel proteins

www.science.org/content/article/bacteria-stitch-exotic-building-blocks-novel-proteins

science

Jan 24, 2024

11

Arf6 as a therapeutic target: Structure, mechanism, and inhibitors

www.sciencedirect.com/science/article/pii/S2211383523002113

Arf6
inihibitor

Jan 24, 2024

9

Movement and space use patterns of black bears in relation to migratory caribou in Northern Quebec and Labrador

corpus.ulaval.ca/entities/publication/80f2a294-ad35-4f32-86a0-fa3ebdce7b4d

hibernation
bear

Jan 23, 2024

1

Parallel genetic excisions of the cardiac troponin I N-terminal extension in tachycardic mammals

www.biorxiv.org/content/10.1101/2023.05.19.541292v2

hibernation
muscle

Jan 23, 2024

1

Physiological properties of the innervated and denervated neuromuscular junction of hibernating and nonhibernating ground squirrels

www.sciencedirect.com/science/article/pii/0014488678900614?via%3Dihub

Jan 23, 2024

21

Primate preoptic neurons drive hypothermia and cold defense

www.cell.com/the-innovation/fulltext/S2666-6758(22)00154-0

hibernation
torpor
hypothalamus
preoptic area

Jan 23, 2024

11

Can mechanistic constraints on recombination reestablishment explain the long-term maintenance of degenerate sex chromosomes?

www.biorxiv.org/content/10.1101/2023.02.17.528909v4

biorxiv

Jan 23, 2024

1

Local translation is engaged to sustain circuit integrity in severed preserved axonal and synaptic projections

www.biorxiv.org/content/10.1101/2023.08.18.553870v2

hibernation
biorxiv
axon degeneration

Jan 23, 2024

1

Co-roosting relationships are consistent across years in a bat maternity group - Scientific Reports

www.nature.com/articles/s41598-023-50191-4

bat

Jan 23, 2024

1

Phospholipase D and phosphatidic acid in the biogenesis and cargo loading of extracellular vesicles: Thematic Review Series: Exosomes and Microvesicles: Lipids as Key Components of their Biogenesis and Functions

www.sciencedirect.com/science/article/pii/S0022227520335252

Arf6-PLD

Jan 20, 2024

1

Localization and regulation of phospholipase D2 by ARF6

onlinelibrary.wiley.com/doi/abs/10.1002/jcb.20351

Arf6
Arf6-PLD

Jan 20, 2024

1

Regulation of Phospholipase D by Arf6 during FcγR-Mediated Phagocytosis

journals.aai.org/jimmunol/article/202/10/2971/862/Regulation-of-Phospholipase-D-by-Arf6-during-Fc-R

Arf6
Arf6-PLD

Jan 20, 2024

11

An Effector Domain Mutant of Arf6 Implicates Phospholipase D in Endosomal Membrane Recycling

www.molbiolcell.org/doi/full/10.1091/mbc.e05-06-0523

Arf6-PLD
Arf6

Jan 20, 2024

22

ARF GTPases and their GEFs and GAPs: concepts and challenges

www.molbiolcell.org/doi/full/10.1091/mbc.E18-12-0820

Arf6

Jan 20, 2024

1

Physiological functions of the small GTPase Arf6 in the nervous system

www.tandfonline.com/doi/full/10.1080/21541248.2015.1043041

Arf6

Jan 20, 2024

22

Arf GTPases and their effectors: assembling multivalent membrane-binding platforms

www-sciencedirect-com.utokyo.idm.oclc.org/science/article/pii/S0959440X14001286?via%3Dihub

Jan 20, 2024

53

Amyloid precursor protein facilitates SARS-CoV-2 virus entry into cells and enhances amyloid-β-associated pathology in APP/PS1 mouse model of Alzheimer’s disease

www.ncbi.nlm.nih.gov/pmc/articles/PMC10725492/

読み会
Research tool
疑問

Jan 19, 2024

11

Pathogenic LRRK2 compromises the subcellular distribution of lysosomes in a Rab12‐RILPL1‐dependent manner

faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202200780RR

IP
Research tool

Jan 19, 2024

11

Arf6 promotes autophagosome formation via effects on phosphatidylinositol 4,5-bisphosphate and phospholipase D

rupress.org/jcb/article-standard/196/4/483/36778/Arf6-promotes-autophagosome-formation-via-effects

Arf6

Jan 18, 2024

11