genken

genken

@genken

Hibernation/Hypothalamus/Sympathetic Neuron/PostDoc/movies

Joined Jan 19, 2023

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7

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721

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iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications

www.sciencedirect.com/science/article/pii/S0092867418302903?via%3Dihub

hibernation
cold tolerance

Apr 8, 2025

1

Coping with the stress: Expression of ATF4, ATF6, and downstream targets in organs of hibernating ground squirrels

www.sciencedirect.com/science/article/pii/S000398610800266X?via%3Dihub

hibernation
cold tolerance

Apr 8, 2025

1

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration - Nature

www.nature.com/articles/nature14142

hibernation
cold tolerance
積読

Apr 8, 2025

Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters

www.sciencedirect.com/science/article/pii/S2211124717317503?via%3Dihub

hibernation
cold tolerance

Apr 8, 2025

1

AIDA directly connects sympathetic innervation to adaptive thermogenesis by UCP1 - Nature Cell Biology

www.nature.com/articles/s41556-021-00642-9

hibernation
sympathetic nervous system
体温制御

Apr 8, 2025

1

Multi-species genome-wide CRISPR screens identify conserved suppressors of cold-induced cell death

www.biorxiv.org/content/10.1101/2024.07.25.605098v4

cold tolerance
hibernation

Apr 8, 2025

1

Graph-based Contrastive Learning Enables Unified Integration and Niche Transfer Across Single-Cell and Spatial Multi-Omics

www.biorxiv.org/content/10.1101/2025.02.19.638965v1

spatial TC
Research tool

Apr 8, 2025

1

mcDETECT: Decoding 3D Spatial Synaptic Transcriptomes with Subcellular-Resolution Spatial Transcriptomics

www.biorxiv.org/content/10.1101/2025.03.27.645744v1?ct=

spatial transcriptomics
Alzheimer's disease
Research tool

Apr 8, 2025

1

future/README_ja.md at develop · futureverse/future

github.com/futureverse/future/blob/develop/README_ja.md

R
future package
Research tool

Apr 2, 2025

11

Seasonal variation in thyrotropin-releasing hormone (TRH) content of different brain regions and the pineal in the mammalian hibernator, Citellus lateralis - PubMed

pubmed.ncbi.nlm.nih.gov/6801738/

Trh
hibernation

Mar 29, 2025

Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons - Nature Neuroscience

www.nature.com/articles/s41593-019-0349-8

scRNAseq
LHA

Mar 29, 2025

Gene expression markers of identity classes — FindMarkers

satijalab.org/seurat/reference/findmarkers

seurat
scRNAseq
bioinformatics

Mar 28, 2025

11

RStudio Server

chromium3.cdb.riken.jp/

Feb 21, 2025

1

Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord

elifesciences.org/articles/92046

spinal cord
spatial TC
scRNAseq

Feb 3, 2025

1

Neuroinflammation in the NTS is associated with changes in cardiovascular reflexes during systemic inflammation - Journal of Neuroinflammation

jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-019-1512-6

積読
交感神経
LPS-induced

Jan 15, 2025

1

Cold Exposure and the Metabolism of Mice, Men, and Other Wonderful Creatures | Physiology

journals.physiology.org/doi/full/10.1152/physiol.00002.2022?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

寒冷暴露

Jan 10, 2025

Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals - Nature Metabolism

www.nature.com/articles/s42255-022-00545-5

hibernation
積読

Jan 6, 2025

1

The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk - Nature Communications

www.nature.com/articles/s41467-024-54080-w

積読

Dec 26, 2024

Stochastic neuropeptide signals compete to calibrate the rate of satiation - Nature

www.nature.com/articles/s41586-024-08164-8

積読

Dec 26, 2024

1

A brain-to-gut signal controls intestinal fat absorption - Nature

www.nature.com/articles/s41586-024-07929-5

積読

Dec 26, 2024

1

Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance - Nature Neuroscience

www.nature.com/articles/s41593-024-01830-0

積読

Dec 26, 2024

1

A brain-to-liver signal mediates the inhibition of liver regeneration under chronic stress in mice - Nature Communications

www.nature.com/articles/s41467-024-54827-5

積読

Dec 26, 2024

Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits - Nature Communications

www.nature.com/articles/s41467-024-53258-6

積読

Dec 26, 2024

1

Hypothalamus-sympathetic-liver axis mediates the early phase of stress-induced hyperglycemia in the male mice - Nature Communications

www.nature.com/articles/s41467-024-52815-3

積読

Dec 26, 2024

1

Excitation-inhibition imbalance in medial preoptic area circuits underlies chronic stress-induced depression-like states - Nature Communications

www.nature.com/articles/s41467-024-52727-2

積読

Dec 26, 2024

1

Light modulates glucose and lipid homeostasis via the sympathetic nervous system

www.science.org/doi/10.1126/sciadv.adp3284

積読

Dec 26, 2024

1

Identification of an ionic mechanism for ERα-mediated rapid excitation in neurons

www.science.org/doi/10.1126/sciadv.adp0696

積読

Dec 26, 2024

1

Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo

www.science.org/doi/10.1126/science.adn6671

積読
review
Research tool

Dec 26, 2024

Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit

www.cell.com/cell/fulltext/S0092-8674(24)00709-8

積読

Dec 26, 2024

1

Structure-guided design of a peripherally restricted chemogenetic system

www.cell.com/cell/fulltext/S0092-8674(24)01275-3

積読

Dec 26, 2024

Transcriptomic cell-type specificity of local cortical circuits

www.cell.com/neuron/fulltext/S0896-6273(24)00651-2

積読

Dec 26, 2024

Leptin-activated hypothalamic BNC2 neurons acutely suppress food intake - Nature

www.nature.com/articles/s41586-024-08108-2

積読

Dec 26, 2024

1

A top-down slow breathing circuit that alleviates negative affect in mice - Nature Neuroscience

www.nature.com/articles/s41593-024-01799-w

積読

Dec 26, 2024

1

Parallel gut-to-brain pathways orchestrate feeding behaviors - Nature Neuroscience

www.nature.com/articles/s41593-024-01828-8

積読

Dec 26, 2024

1

Feedforward inhibition of stress by brainstem neuropeptide Y neurons - Nature Communications

www.nature.com/articles/s41467-024-51956-9

積読

Dec 25, 2024

1

Distinct medial amygdala oxytocin receptor neurons projections respectively control consolation or aggression in male mandarin voles - Nature Communications

www.nature.com/articles/s41467-024-51652-8

積読

Dec 25, 2024

1

Tak1 licenses mitochondrial transfer from astrocytes to POMC neurons to maintain glucose and cholesterol homeostasis

www.cell.com/cell-reports/fulltext/S2211-1247(24)01334-2

積読

Dec 25, 2024

1

Endogenous nitric oxide derived from NOS I or II in thoracic spinal cord exerts opposing tonic modulation on sympathetic vasomotor tone via disparate mechanisms in anesthetized rats | American Journal of Physiology-Heart and Circulatory Physiology

journals.physiology.org/doi/full/10.1152/ajpheart.00246.2016

交感神経
交感神経
NOS
NOS

Dec 19, 2024

Sympathetic preganglionic neurons contain nitric oxide synthase and project to the superior cervical ganglion: Combined application of retrograde neuronal tracer and NADPH-diaphorase histochemistry

www.sciencedirect.com/science/article/abs/pii/036192309400234R?via%3Dihub

交感神経
交感神経
NOS

Dec 18, 2024

Nitric oxide and excitatory postsynaptic currents in immature rat sympathetic preganglionic neurons in vitro

www.sciencedirect.com/science/article/pii/S0306452296006124?via%3Dihub

交感神経
NOS
NOS

Dec 18, 2024

Calcium-activated release of nitric oxide potentiates excitatory synaptic potentials in immature rat sympathetic preganglionic neurons | Journal of Neurophysiology

journals.physiology.org/doi/abs/10.1152/jn.1995.74.6.2600?checkFormatAccess=true

交感神経
交感神経
NOS
NOS

Dec 18, 2024

Evidence for a critical role of nitric oxide in the tonic excitation of rabbit renal sympathetic preganglionic neurones - PMC

pmc.ncbi.nlm.nih.gov/articles/PMC1157738/

交感神経
交感神経
NOS

Dec 18, 2024

Axonal transport of nitric oxide synthase in autonomic nerves

www.sciencedirect.com/science/article/abs/pii/0165183895000690?via%3Dihub

交感神経
交感神経
NOS

Dec 18, 2024

The neurobiology of parenting and infant-evoked aggression | Physiological Reviews

journals.physiology.org/doi/full/10.1152/physrev.00036.2023?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

積読
review
養育行動

Dec 17, 2024

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model - Nature Communications

www.nature.com/articles/s41467-019-11674-z

microglia
PLX5622

Dec 16, 2024

Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor | NEJM

www.nejm.org/doi/10.1056/NEJMoa1411366

microglia
PLX3397

Dec 16, 2024

New Map of Mouse Spinal Cord Provides a Reference for Science and Disease

zuckermaninstitute.columbia.edu/new-map-mouse-spinal-cord-provides-reference-science-and-disease

spinal cord

Dec 9, 2024

PACAP signaling in stress: insights from the chromaffin cell - Pflügers Archiv - European Journal of Physiology

link.springer.com/article/10.1007/s00424-017-2062-3

PACAP
PACAP
交感神経
交感神経
review

Dec 3, 2024

BPS Publications

bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/j.1476-5381.2012.02045.x

PACAP
交感神経
交感神経

Dec 3, 2024

1

PACAP induces bradycardia in guinea-pig heart by stimulation of atrial cholinergic neurones - Naunyn-Schmiedeberg's Archives of Pharmacology

link.springer.com/article/10.1007/BF00168432

PACAP

Dec 3, 2024

11