The Proliferation of COVID Variants | Summary and Q&A

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September 9, 2021
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The Proliferation of COVID Variants

TL;DR

Immunobiologist predicts vaccine issues leading to variant evolution, suggesting a need for reevaluation.

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Key Insights

  • ⌛ Narrowly targeted COVID-19 vaccines could contribute to the evolution of variant strains, reducing their effectiveness over time.
  • ❓ Traditional vaccines offer full immunity compared to leaky vaccines that create evolutionary pressure on pathogens.
  • 👍 Garrett Vandenbush's predictions regarding vaccine issues and variant evolution have proven accurate, highlighting the need for reevaluation in vaccine development.
  • 💉 The public health apparatus may need a rethink to better serve individual and collective well-being in managing health crises.

Transcript

The Joe Rogan Experience Garrett vandenbush said this is going to become a pandemic of variance and he talked about immune escape and that has been very controversial but did you explain that to people sure what he argued and let's just say could you explain who he is too sure he is a uh immunobiologist he is training his Veterinary he has training... Read More

Questions & Answers

Q: Who is Garrett Vandenbush, and what did he predict regarding vaccines and variants?

Garrett Vandenbush is an immunobiologist who warned that narrowly targeted vaccines could lead to variant evolution, evading immunity created by the vaccines.

Q: Why are traditional vaccines different from the narrow-targeted vaccines deployed in the COVID-19 pandemic?

Traditional vaccines offer full sterilizing immunity, while the COVID-19 vaccines are leaky, creating intense evolutionary pressure on pathogens to change and evade immunity.

Q: How do vaccines contribute to the evolutionary pressure for radiation of variants?

By targeting a single subunit of a protein in the spike of the virus, vaccines create an environment where variants can evolve to escape immune recognition, leading to breakthrough cases.

Q: What implications does Vandenbush's predictions have for the future of vaccine development?

Vandenbush's warnings highlight the need for reevaluation and potential modifications in vaccine development to address evolving variants and improve long-term immunity.

Summary

In this video, Joe Rogan discusses the concept of immune escape and the potential for a pandemic of variance with immunobiologist Garrett vandenbush. Vandenbush argues that the narrow targeting of vaccines and their deployment during an active pandemic create intense evolutionary pressure on the spike protein, leading to the emergence of variants that can evade vaccine-induced immunity. He accurately predicted the phenomenon of breakthrough cases and highlights the need for modified vaccines to address this issue. The vaccines, while a remarkable technological achievement, have failed to produce lasting and broad immunity compared to natural immunity from the disease. Rogan emphasizes the importance of rethinking our approach to managing the pandemic and suggests that vested interests in the pharmaceutical industry may influence decision-making.

Questions & Answers

Q: Who is Garrett vandenbush and what is his expertise?

Garrett vandenbush is an immunobiologist with training in Veterinary Vaccination technology. He has appeared as a guest on Joe Rogan's podcast and has a reputation for offering technical insights in a non-technical manner.

Q: What did Garrett vandenbush argue regarding the vaccines and their deployment?

Vandenbush argued that the vaccines being deployed are narrowly targeted, containing a single subunit of a protein. He highlights the unusual aspect of deploying these vaccines during an active pandemic. This approach creates conditions where the spike protein, the antigen targeted by the vaccine, is under intense evolutionary pressure to change. As a result, the immunity induced by the vaccines can be evaded by the pathogen, leading to breakthrough cases.

Q: What is the consequence of vaccine-induced evolutionary pressure on the spike protein?

The intense evolutionary pressure exerted on the spike protein due to the narrow targeting of the vaccines increases the likelihood of changes in the molecular signatures of the protein. These changes can make the vaccines less effective at producing immunity, reducing their overall effectiveness.

Q: Did Garrett vandenbush accurately predict the emergence of variants and the reduced effectiveness of vaccines?

Yes, Vandenbush accurately predicted the impact of intense evolutionary pressure on the spike protein and the resulting emergence of variants. His ability to foresee these events raises questions about the expertise and decision-making of traditional experts in the field.

Q: Are the vaccines ready for prime time or are they still in a prototype stage?

While the vaccines are a remarkable achievement from a technological standpoint, they can be considered prototypes. They have achieved something unprecedented, but they have failed to produce lasting immunity and provide a less broad immunity compared to natural immunity obtained from having the disease. A rethinking of the approach is necessary.

Q: How has our understanding of managing the disease evolved?

Our understanding of managing the disease has improved significantly, leading to reduced lethality. This suggests that a reevaluation of our approach to the pandemic is warranted, taking into account the lessons learned and the tools now available to effectively manage the crisis.

Q: Why is there hesitation in modifying the vaccines to address their limitations?

It is unclear why there is hesitancy in modifying the vaccines to mitigate their limitations. It is worth noting that successfully managing the pandemic would disrupt a significant flow of revenue into the pharmaceutical market, which may influence decision-making. The public needs to recognize that their interests are not being adequately served by the current public health apparatus.

Q: What are the implications of errors made by the public health apparatus?

The errors made by the public health apparatus have implications for both individual health and collective well-being. A reevaluation of our approach is necessary to ensure the best possible outcomes for public health.

Q: What is the suggested course of action based on the insights provided?

Based on the insights shared by experts who have successfully treated the disease and accurately predicted events such as the emergence of variants, it appears that we now have the tools to effectively manage the crisis and overcome it. However, there is a need for a collective recognition of the errors made by the public health apparatus and a willingness to rethink our current approach.

Takeaways

The discussion highlights the concept of immune escape and the potential consequences of deploying narrowly targeted vaccines during an active pandemic. Vandenbush accurately predicted the emergence of variants and the reduced effectiveness of the vaccines. While the vaccines are a technological achievement, they are prototypes that require modification to address their limitations. The public health apparatus needs to be scrutinized for errors that hinder the effective management of the pandemic. By reevaluating our approach and utilizing the tools available, it is possible to manage the crisis effectively and improve both individual health and collective well-being.

Summary & Key Takeaways

  • Garrett Vandenbush, an immunobiologist, warns of the potential for vaccines to create evolutionary pressure on pathogens, leading to variant strains.

  • Traditional vaccines provide full immunity, unlike the narrow-targeted vaccines deployed during the COVID-19 pandemic.

  • Vaccines may need modification to address breakthrough cases and evolving variants for more effective immunity.

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