Biology Inheritance Principle part 42 (Mendelian Disorder: Sickle Cell anaemia) class 12 XII | Summary and Q&A

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May 11, 2015
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Biology Inheritance Principle part 42 (Mendelian Disorder: Sickle Cell anaemia) class 12 XII

TL;DR

This video explains the causes and inheritance patterns of sickle cell anemia and phenylketonuria, two common Mendelian disorders.

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Questions & Answers

Q: What is the main characteristic of sickle cell anemia?

Sickle cell anemia is characterized by misshapen red blood cells that are sickle-shaped instead of rounded, leading to complications and decreased oxygen levels in the body.

Q: How does a mutation in the gene for hemoglobin affect its production?

A mutation in the gene for hemoglobin can lead to the production of abnormal proteins, resulting in misshapen red blood cells and decreased hemoglobin levels, causing sickle cell anemia.

Q: How is sickle cell anemia inherited?

Sickle cell anemia is inherited in an autosomal recessive manner, meaning a person needs to inherit two copies of the mutated gene, one from each parent, to develop the disorder.

Q: What is phenylketonuria and how does it occur?

Phenylketonuria is an inborn error of metabolism caused by a deficiency in the enzyme phenylalanine hydroxylase, leading to the accumulation of phenylalanine and potential mental retardation.

Q: How is phenylketonuria inherited?

Phenylketonuria is also inherited in an autosomal recessive manner, requiring a person to inherit two copies of the mutated gene for phenylalanine hydroxylase to be affected.

Summary & Key Takeaways

  • Sickle cell anemia is a genetic disorder characterized by misshapen red blood cells due to a mutation in the gene that codes for hemoglobin.

  • Phenylketonuria is an inborn error of metabolism caused by a lack of the enzyme that metabolizes phenylalanine, leading to its accumulation and potential mental retardation.

  • Both disorders are inherited in an autosomal recessive manner, meaning a person needs to inherit the mutated gene from both parents to be affected.

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