Y-T Tsai
@e7chjxhp7dvu8kbn
Joined May 21, 2023
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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation - Nature Structural & Molecular Biology
www.nature.com/articles/s41594-023-01162-w
Dec 13, 2024
3 Highlights
Enhancer RNAs: mechanisms in transcriptional regulation and functions in diseases - Cell Communication and Signaling
biosignaling.biomedcentral.com/articles/10.1186/s12964-023-01206-0
Dec 7, 2024
1 Highlights
Zenodo
zenodo.org/
Nov 25, 2024
1 Highlights
Meiosis: the chromosomal foundation of reproduction
academic.oup.com/biolreprod/article/99/1/112/4828314?login=false
Nov 13, 2024
5 Highlights
Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy
academic.oup.com/brain/article/140/1/184/2452355
Nov 13, 2024
1 Highlights
Mammalian Germ Cell Development: From Mechanism to In Vitro Reconstitution
www.cell.com/stem-cell-reports/fulltext/S2213-6711(21)00038-2
Nov 5, 2024
6 Highlights
Toward the quantification of α-synuclein aggregates with digital seed amplification assays | PNAS
www.pnas.org/doi/10.1073/pnas.2312031121
Nov 3, 2024
1 Highlights & 1 Notes
Distinct tau and alpha-synuclein molecular signatures in Alzheimer’s disease with and without Lewy bodies and Parkinson’s disease with dementia - Acta Neuropathologica
link.springer.com/article/10.1007/s00401-023-02657-y
Nov 3, 2024
5 Highlights & 1 Notes
RNA helicase D1PAS1 resolves R-loops and forms a complex for mouse pachytene piRNA biogenesis required for male fertility
academic.oup.com/nar/article/52/19/11973/7736807?login=false
Nov 2, 2024
2 Highlights
Genomic profiling of native R loops with a DNA-RNA hybrid recognition sensor
www.science.org/doi/10.1126/sciadv.abe3516
Nov 2, 2024
4 Highlights
Application of Cryotechniques with Freeze-substitution for the Immunohistochemical Demonstration of Intranuclear pCREB and Chromosome Territory - Nobuhiko Ohno, Nobuo Terada, Shin-ichi Murata, Ryohei Katoh, Shinichi Ohno, 2005
journals.sagepub.com/doi/10.1177/002215540505300107?icid=int.sj-full-text.similar-articles.3
Nov 2, 2024
1 Highlights
Recent advances of PIWI‐interacting RNA in cardiovascular diseases - PMC
pmc.ncbi.nlm.nih.gov/articles/PMC11290350/
Oct 26, 2024
1 Highlights
Decay of Piwi-Interacting RNAs in Human Cells Is Primarily Mediated by 5' to 3' Exoribonucleases - PubMed
pubmed.ncbi.nlm.nih.gov/35687865/
Oct 26, 2024
1 Highlights
Super-enhancer switching drives a burst in gene expression at the mitosis-to-meiosis transition - Nature Structural & Molecular Biology
www.nature.com/articles/s41594-020-0488-3
Oct 15, 2024
1 Highlights
On mice and men with asthma | Science Surf
www.wjst.de/blog/sciencesurf/2006/12/on-mice-and-men-with-asthma/
Oct 6, 2024
7 Highlights
SNHG25 promotes colorectal cancer metastasis by regulating MMP2 - PubMed
pubmed.ncbi.nlm.nih.gov/37751586/
Sep 17, 2024
1 Highlights
Targeting pericentric non-consecutive motifs for heterochromatin initiation - Nature
www.nature.com/articles/s41586-024-07640-5
Sep 16, 2024
9 Highlights
Mammalian Small Nucleolar RNAs Are Mobile Genetic Elements
journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.0020205
Sep 5, 2024
5 Highlights
Do repeated arrays of regulatory small‐RNA genes elicit genomic imprinting?
onlinelibrary.wiley.com/doi/10.1002/bies.201100032
Sep 5, 2024
7 Highlights
Cancer and meiotic gene expression: Two sides of the same coin?
www.sciencedirect.com/science/article/pii/S0070215322000874
Sep 4, 2024
11 Highlights & 2 Notes
Tau’s function and dysfunction in the brain: when small... : Neural Regeneration Research
journals.lww.com/nrronline/fulltext/2024/01000/tau_s_function_and_dysfunction_in_the_brain__when.23.aspx
Sep 1, 2024
12 Highlights
Mechanical regulation of chromatin and transcription - Nature Reviews Genetics
www.nature.com/articles/s41576-022-00493-6?fromPaywallRec=false
Aug 19, 2024
1 Highlights
The tethering of chromatin to the nuclear envelope supports nuclear mechanics - Nature Communications
www.nature.com/articles/ncomms8159
Aug 19, 2024
5 Highlights
Expression of CD90 on keratinocyte stem/progenitor cells
academic.oup.com/bjd/article-abstract/154/6/1062/6637159?redirectedFrom=fulltext&login=false
Aug 6, 2024
1 Highlights
Laminin Coating Protocol for Cell Culture
www.sigmaaldrich.com/TW/en/technical-documents/protocol/cell-culture-and-cell-culture-analysis/3d-cell-culture/laminin-product-protocols
Aug 6, 2024
5 Highlights
Zotero | Your personal research assistant
www.zotero.org/start
Aug 3, 2024
1 Highlights
Advances in Isolation Methods for Spermatogonial Stem Cells - Stem Cell Reviews and Reports
link.springer.com/article/10.1007/s12015-015-9632-6
Aug 3, 2024
8 Highlights
Hormones of the Reproductive System
www.biology-pages.info/S/SexHormones.html
Aug 3, 2024
1 Highlights
Energy Constraint as a Novel Mechanism Linking Exercise and Health | Physiology
journals.physiology.org/doi/full/10.1152/physiol.00027.2018
Aug 2, 2024
3 Highlights
Sex difference in Alzheimer's disease: An updated, balanced and emerging perspective on differing vulnerabilities - PubMed
pubmed.ncbi.nlm.nih.gov/33008530/
Aug 1, 2024
1 Highlights
Changing Identities: Imaging Endosomal Maturation
www.the-scientist.com/changing-identities-imaging-endosomal-maturation-72032
Aug 1, 2024
6 Highlights
Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level - Molecular Neurodegeneration
link.springer.com/article/10.1186/1750-1326-10-1
Aug 1, 2024
1 Highlights
5xFAD (B6SJL) | ALZFORUM
www.alzforum.org/research-models/5xfad-b6sjl
Aug 1, 2024
1 Highlights
Molecular Differences and Similarities between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis - Chera L. Maarouf, Tyler A. Kokjohn, Charisse M. Whiteside, MiMi P. Macias, Walter M. Kalback, Marwan N. Sabbagh, Thomas G. Beach, Robert Vassar, Alex E. Roher, 2013
journals.sagepub.com/doi/10.4137/BCI.S13025
Aug 1, 2024
1 Highlights
Systematic phenotyping and characterization of the 5xFAD mouse model of Alzheimer’s disease - Scientific Data
www.nature.com/articles/s41597-021-01054-y
Aug 1, 2024
1 Highlights
Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation
www.jneurosci.org/content/26/40/10129
Aug 1, 2024
1 Highlights & 1 Notes
How to build your secret repertoire
vanschneider.com/blog/how-to-build-your-secret-repertoire/
Jul 24, 2024
4 Highlights
A noncanonical enzymatic function of PIWIL4 maintains genomic integrity and leukemic growth in AML
ashpublications.org/blood/article/142/1/90/495678/A-noncanonical-enzymatic-function-of-PIWIL4
Jul 17, 2024
8 Highlights
Frontiers | R-loops in normal and malignant hematopoiesis
www.frontiersin.org/journals/hematology/articles/10.3389/frhem.2023.1297657/full
Jul 17, 2024
7 Highlights & 1 Notes
The Nucleus’ Secret to Shapeshifting
www.the-scientist.com/the-nucleus-secret-to-shapeshifting-71891
Jul 17, 2024
2 Highlights
HDAC8 inhibition ameliorates pulmonary fibrosis | American Journal of Physiology-Lung Cellular and Molecular Physiology
journals.physiology.org/doi/full/10.1152/ajplung.00551.2017
Jul 15, 2024
3 Highlights
A direct role for small non-coding RNAs in DNA damage response
www.sciencedirect.com/science/article/pii/S0962892413001657
Jul 9, 2024
4 Highlights
FXR1 Gene - GeneCards | FXR1 Protein | FXR1 Antibody
www.genecards.org/cgi-bin/carddisp.pl?gene=FXR1
Jul 9, 2024
3 Highlights
In vitro spermatogenesis: Why meiotic checkpoints matter
www.sciencedirect.com/science/article/pii/S0070215322000722
Jul 9, 2024
2 Highlights
DNA repair mediated by endonuclease-independent LINE-1 retrotransposition - Nature Genetics
www.nature.com/articles/ng898z
Jul 3, 2024
1 Highlights
Count normalization with DESeq2
hbctraining.github.io/DGE_workshop_salmon_online/lessons/02_DGE_count_normalization.html
Jun 30, 2024
1 Highlights
Progress on the roles of MEF2C in neuropsychiatric diseases - Molecular Brain
molecularbrain.biomedcentral.com/articles/10.1186/s13041-021-00892-6
Jun 26, 2024
5 Highlights
CDK5RAP1 Gene - GeneCards | CK5P1 Protein | CK5P1 Antibody
www.genecards.org/cgi-bin/carddisp.pl?gene=CDK5RAP1
Jun 25, 2024
4 Highlights
Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis - PubMed
pubmed.ncbi.nlm.nih.gov/12691662/
Jun 25, 2024
1 Highlights
MEF2C ameliorates learning, memory, and molecular pathological changes in Alzheimer’s disease in vivo and in vitro - PubMed
pubmed.ncbi.nlm.nih.gov/35130621/
Jun 25, 2024
2 Highlights
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis - PubMed
pubmed.ncbi.nlm.nih.gov/11904443/
Jun 25, 2024
2 Highlights
Importance of DNA fragmentation in apoptosis with regard to TUNEL specificity
www.sciencedirect.com/science/article/abs/pii/S0753332298800103?via%3Dihub
Jun 24, 2024
2 Highlights
Human Germline Cell Development: from the Perspective of Single-Cell Sequencing
www.cell.com/molecular-cell/fulltext/S1097-2765(19)30664-1
Jun 19, 2024
22 Highlights
Single-cell DNA methylome sequencing of human preimplantation embryos - Nature Genetics
www.nature.com/articles/s41588-017-0007-6
Jun 19, 2024
1 Highlights
Transposable Elements: Emerging Therapeutic Targets in Neurodegenerative Diseases - Neurotoxicity Research
link.springer.com/article/10.1007/s12640-024-00688-1
Jun 16, 2024
9 Highlights & 1 Notes
Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease - Nature Structural & Molecular Biology
www.nature.com/articles/s41594-024-01320-8
Jun 16, 2024
5 Highlights & 1 Notes
Cytoplasmic chromatin fragments—from mechanisms to therapeutic potential
elifesciences.org/articles/63728
Jun 11, 2024
6 Highlights
Circular DNA in the human germline and its association with recombination
www.cell.com/molecular-cell/fulltext/S1097-2765(21)01029-7?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1097276521010297%3Fshowall%3Dtrue
Jun 7, 2024
3 Highlights
Circular DNA in the human germline and its association with recombination - PubMed
pubmed.ncbi.nlm.nih.gov/34951964/
Jun 7, 2024
3 Highlights
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases - Signal Transduction and Targeted Therapy
www.nature.com/articles/s41392-022-01176-8
Jun 7, 2024
6 Highlights
Neural Economics: Understanding the Brain’s Energy Budget — BrainPost | Easy-to-read summaries of the latest neuroscience publications
www.brainpost.co/weekly-brainpost/2024/6/4/neural-economics-understanding-the-brains-energy-budget
Jun 5, 2024
3 Highlights
Neuropathologically mixed Alzheimer's and Lewy body disease: burden of pathological protein aggregates differs between clinical phenotypes - PubMed
pubmed.ncbi.nlm.nih.gov/25758940/
May 29, 2024
2 Highlights & 2 Notes
Prevalence of Concomitant Pathologies in Parkinson’s Disease: Implications for Prognosis, Diagnosis, and Insights into Common Pathogenic Mechanisms - IOS Press
content.iospress.com/articles/journal-of-parkinsons-disease/jpd230154
May 29, 2024
13 Highlights & 1 Notes
Dysregulation of Human Somatic piRNA Expression in Parkinson’s Disease Subtypes and Stages
www.mdpi.com/1422-0067/23/5/2469
May 29, 2024
3 Highlights
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies - Nature Reviews Neuroscience
www.nature.com/articles/nrn3549
May 24, 2024
8 Highlights
Neuropathologic substrates of Parkinson disease dementia
onlinelibrary.wiley.com/doi/10.1002/ana.23659
May 24, 2024
3 Highlights
Age‐related and species‐specific methylation changes in the protein‐coding marmoset sperm epigenome
onlinelibrary.wiley.com/doi/10.1111/acel.14200
May 20, 2024
7 Highlights
A global phosphosite-correlated network map of Thousand And One Kinase 1 (TAOK1)
www.sciencedirect.com/science/article/pii/S1357272524000499
May 19, 2024
2 Highlights
Mitochondrial membrane-based initial separation of MIWI and MILI functions during pachytene piRNA biogenesis
academic.oup.com/nar/article/47/5/2594/5258025
May 18, 2024
9 Highlights
Relaxed targeting rules help PIWI proteins silence transposons - Nature
www.nature.com/articles/s41586-023-06257-4?fromPaywallRec=false
May 18, 2024
7 Highlights
D-lactate dehydrogenase, membrane binding (PF09330) - Pfam entry - InterPro
www.ebi.ac.uk/interpro/entry/pfam/PF09330/
May 17, 2024
1 Highlights & 1 Notes
Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum - BMC Neuroscience
bmcneurosci.biomedcentral.com/articles/10.1186/s12868-014-0137-z
May 12, 2024
5 Highlights
A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis
www.sciencedirect.com/science/article/pii/S0092867419312784?via%3Dihub
May 9, 2024
4 Highlights
Anchor-based bisulfite sequencing determines genome-wide DNA methylation - Communications Biology
www.nature.com/articles/s42003-022-03543-1
May 7, 2024
2 Highlights
Supersaturated designs: A review of their construction and analysis
www.sciencedirect.com/science/article/pii/S0378375812003084
May 3, 2024
21 Highlights
Beyond antiviral: role of IFN-I in brain development
www.cell.com/trends/immunology/fulltext/S1471-4906(24)00073-5?rss=yes
Apr 21, 2024
3 Highlights
Condensed Mitochondria Assemble Into the Acrosomal Matrix During Spermiogenesis
www.frontiersin.org/articles/10.3389/fcell.2022.867175/full
Apr 18, 2024
4 Highlights
Genome-wide association study identifies a new susceptibility locus in PLA2G4C for Multiple System Atrophy
www.medrxiv.org/content/10.1101/2023.05.02.23289328v1.full-text
Apr 18, 2024
3 Highlights
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev2.12404
Apr 16, 2024
5 Highlights
Friends and Foes: Astrocytes as Disease Targets
www.the-scientist.com/friends-and-foes-astrocytes-as-disease-targets-71768
Apr 10, 2024
3 Highlights
Natural display of nuclear-encoded RNA on the cell surface and its impact on cell interaction - Genome Biology
genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02145-6
Apr 5, 2024
7 Highlights
Small RNAs are modified with N-glycans and displayed on the surface of living cells
www.sciencedirect.com/science/article/pii/S0092867421005031?via%3Dihub
Apr 5, 2024
4 Highlights
Ribosome-guided piRNA production - Nature Cell Biology
www.nature.com/articles/s41556-020-0464-5
Apr 3, 2024
15 Highlights
RNA 2′-O-Methylation (Nm) Modification in Human Diseases
www.mdpi.com/2073-4425/10/2/117
Apr 3, 2024
5 Highlights