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Metastasis
www.sciencedirect.com
Scientists are still trying to understand the biological basis underlying the dissemination and outgrowth of tumor cells, why these cells can remain dormant for years, how they become resistant to the immune system or cytotoxic effects of systemic therapy, and how they interact with their new microe
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  • Scientists are still trying to understand the biological basis underlying the dissemination and outgrowth of tumor cells, why these cells can remain dormant for years, how they become resistant to the immune system or cytotoxic effects of systemic therapy, and how they interact with their new microenvironment.
  • One opportunity involves therapies targeting premetastatic niches (PMNs), defined as those inflamed distant environments rendered favorable to supporting tumor metastasis under the influence of tumor-secreted soluble factors and tumor-shed extracellular vesicles (EVs).
  • The hallmark of the PMN is the co-existence of multiple pathological changes even prior to the arrival of metastatic tumor cells.
  • Mounting clinical evidence documents the presence of PMNs in cancer patients, in lymph nodes as well as in distant tissues such as the omentum and liver
  • The detection of PMNs will require synergistic approaches combining new imaging tools, such as SPECT/PET and ultrahigh magnetic field MRI, biopsies of lymph nodes and distant organs, and examination of tumor-secreted biomarkers, such as tissue and plasma-derived EV proteins, DNA, and RNA.

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