Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes | PNAS thumbnail
Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes | PNAS
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Despite improved understanding of the activation process, how Ca2+ release is terminated remains unclear. CICR, with its inherent positive feedback, is expected to operate in an “all-or-none” fashion. Regenerative activation of multiple RyRs within the release units should result in long-lasting Ca2
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  • Despite improved understanding of the activation process, how Ca2+ release is terminated remains unclear. CICR, with its inherent positive feedback, is expected to operate in an “all-or-none” fashion. Regenerative activation of multiple RyRs within the release units should result in long-lasting Ca2+ sparks and unstable global Ca2+ oscillations. Ho...
  • We tested specifically (i) whether increasing open-duration and enhancing reopenings of Ca2+ channels prolongs Ca2+ release and triggers secondary Ca2+ release, respectively, (ii) whether the SR Ca2+ is depleted after a maximal Ca2+ release induced by ICa, and (iii) whether RyRs can be reactivated by a stronger Ca2+ stimulus immediately subsequent ...

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