Higher oxygen content and transport characterize high-altitude ethnic Tibetan women with the highest lifetime reproductive success | PNAS thumbnail
Higher oxygen content and transport characterize high-altitude ethnic Tibetan women with the highest lifetime reproductive success | PNAS
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Considering the collective contributions of sociocultural factors and the multiple biological traits contributing to the internal environment provided a fresh way to test hypotheses about ongoing natural selection under the stress of high-altitude hypoxia. to examine the hypothesis that multiple oxy
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Summary

- 🌄 **High-Altitude Adaptation**: Ethnic Tibetan women exhibit unique biological traits that enhance oxygen delivery, crucial for thriving in high-altitude hypoxic environments.
- 🧬 **Genomic Insights**: The study identifies significant genomic associations, particularly with the EPAS1 locus, linked to hemoglobin concentration and oxygen saturation, indicating ongoing natural selection.
- 👶 **Reproductive Success**: Higher oxygen saturation correlates with increased lifetime reproductive success, while extreme hemoglobin levels are associated with fewer live births.
- 🔍 **Natural Selection Evidence**: The research highlights stabilizing selection on hemoglobin concentration and directional selection favoring higher oxygen saturation among Tibetan populations.
- 📊 **Comprehensive Approach**: Integrating reproductive histories, sociocultural factors, physiology, and genotypes is essential for understanding natural selection's impact on adaptive human phenotypes in extreme environments.

Top Highlights

  • Considering the collective contributions of sociocultural factors and the multiple biological traits contributing to the internal environment provided a fresh way to test hypotheses about ongoing natural selection under the stress of high-altitude hypoxia.
  • to examine the hypothesis that multiple oxygen delivery traits were associated with lifetime reproductive success and had genomic associations
  • We propose ongoing stabilizing selection on hemoglobin concentration because extreme values predicted fewer livebirths and directional selection favoring higher oxygen saturation because higher values had more predicted livebirths.
  • EPAS1, an oxygen homeostasis locus with strong signals of positive natural selection and a high frequency of variants occurring only among populations indigenous to the Tibetan Plateau, associated with hemoglobin concentration.
  • Testing the hypothesis of natural selection acting on adaptive human phenotypes requires integrating many data sources, including reproductive histories, sociocultural factors, physiology, and genotypes. Populations with a long history of exposure to severe stress and the opportunity for natural selection provide an ideal context to address these c...

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