Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network
tanycytes, engineered to express channelrhodopsin, can activate arcuate neurons to induce acute hyperphagia when activated by light.
Activation of tanycytes ex vivo depolarized orexigenic (neuropeptide Y/agouti-related protein; NPY/AgRP) and anorexigenic (proopiomelanocortin; POMC) neurons via an ATP-dependent mechanism.
activation of tanycytes triggered acute hyperphagia only in the fed state during the inactive phase of the light–dark cycle.
we also demonstrated that tanycytes can induce membrane potential changes in POMC-expressing neurons.
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