and the ability of biomolecules to bind weakly to one another through nonspecific and promiscuous binding sites (e.g., via charge–charge, dipole–dipole, � – � , and cation– � interactions)
governing the stability and composition of multicomponent biomolecular condensates.
molecular connectivity of condensates are present in higher concentrations because connectivity is positively correlated with stability.
Hence, composition of highly multicomponent condensates can be predicted from the critical points of reduced-component mixtures.
number of weak attractive protein–protein interactions per unit of volume—determines the stability (e.g., in temperature, pH, salt concentration) of multicomponent condensates, where stability is positively correlated with connectivity.
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