Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components | Proceedings of the National Academy of Sciences thumbnail
Liquid network connectivity regulates the stability and composition of biomolecular condensates with many components | Proceedings of the National Academy of Sciences
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and the ability of biomolecules to bind weakly to one another through nonspecific and promiscuous binding sites (e.g., via charge–charge, dipole–dipole, � – � , and cation– � interactions) governing the stability and composition of multicomponent biomolecular condensates. molecular connectivity of
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  • and the ability of biomolecules to bind weakly to one another through nonspecific and promiscuous binding sites (e.g., via charge–charge, dipole–dipole, � – � , and cation– � interactions)
  • governing the stability and composition of multicomponent biomolecular condensates.
  • molecular connectivity of condensates are present in higher concentrations because connectivity is positively correlated with stability.
  • Hence, composition of highly multicomponent condensates can be predicted from the critical points of reduced-component mixtures.
  • number of weak attractive protein–protein interactions per unit of volume—determines the stability (e.g., in temperature, pH, salt concentration) of multicomponent condensates, where stability is positively correlated with connectivity.

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