CA consists of two subdomains CA-NTD (N-terminal domain) and CA-CTD (C-terminal domain). High-resolution structures are available for multiple CA-NTD and CA-CTD domains, including HIV-1 (lentivirus), Rous sarcoma virus (an alpharetrovirus), Mason–Pfizer monkey virus (a betaretrovirus), and murine leukemia virus (MLV; a gammaretrovirus) (17–22). Gag...
Ty1 and Ty3 Gag proteins, together with lesser amounts of Gag-Pol, form roughly spherical virus-like particles of variable sizes within cells (36–39) that also undergo proteolytic maturation. In the case of Ty3, Gag3 is cleaved into CA and NC domains (40). Formation of the capsid is important for genome protection and is an essential step in the re...
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