Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs | Proceedings of the National Academy of Sciences thumbnail
Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs | Proceedings of the National Academy of Sciences
www.pnas.org
resistance allele creation can be prevented through the use of guide RNAs designed to cleave a gene at four target sites. A gene drive method of particular interest for population suppression utilizes homing endonuclease genes (HEGs), wherein a site-specific, nuclease-encoding cassette is copied, in
1 Users
0 Comments
6 Highlights
1 Notes

Top Highlights

  • resistance allele creation can be prevented through the use of guide RNAs designed to cleave a gene at four target sites.
  • A gene drive method of particular interest for population suppression utilizes homing endonuclease genes (HEGs), wherein a site-specific, nuclease-encoding cassette is copied, in the germline, into a target gene whose loss of function results in loss of viability or fertility in homozygous, but not heterozygous, progeny.
  • genes required for embryonic viability or fertility

Ready to highlight and find good content?

Glasp is a social web highlighter that people can highlight and organize quotes and thoughts from the web, and access other like-minded people’s learning.