resistance allele creation can be prevented through the use of guide RNAs designed to cleave a gene at four target sites.
A gene drive method of particular interest for population suppression utilizes homing endonuclease genes (HEGs), wherein a site-specific, nuclease-encoding cassette is copied, in the germline, into a target gene whose loss of function results in loss of viability or fertility in homozygous, but not heterozygous, progeny.
genes required for embryonic viability or fertility
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