Normal aging induces A1-like astrocyte reactivity | Proceedings of the National Academy of Sciences thumbnail
Normal aging induces A1-like astrocyte reactivity | Proceedings of the National Academy of Sciences
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In aging, the brain becomes vulnerable to injury and cognitive function declines, Astrocytes instruct the formation, maturation, and elimination of synapses, and impairment of these functions has been implicated in many diseases. Th We used the Bac-Trap method to perform RNA sequencing of astrocytes
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  • In aging, the brain becomes vulnerable to injury and cognitive function declines,
  • Astrocytes instruct the formation, maturation, and elimination of synapses, and impairment of these functions has been implicated in many diseases. Th
  • We used the Bac-Trap method to perform RNA sequencing of astrocytes from different brain regions across the lifespan of the mouse.
  • aged astrocytes take on a reactive phenotype of neuroinflammatory A1-like reactive astrocytes
  • Since A1 reactive astrocytes lose the ability to carry out their normal functions, produce complement components, and release a toxic factor which kills neurons and oligodendrocytes, the aging-induced up-regulation of reactive genes by astrocytes could contribute to the cognitive decline in vulnerable brain regions in normal aging and contribute to...

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