Cholesterol provides nonsacrificial protection of membrane lipids from chemical damage at air–water interface | Proceedings of the National Academy of Sciences thumbnail
Cholesterol provides nonsacrificial protection of membrane lipids from chemical damage at air–water interface | Proceedings of the National Academy of Sciences
www.pnas.org
For both bilayer and monolayer membranes, experimental and theoretical efforts have provided evidence that cholesterol has unique abilities to increase the order of lipid packing (1–4), lower the permeability (5, 6), and maintain the fluidity and diffusion rate (1, 2, 4) at the same time. It increas
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  • For both bilayer and monolayer membranes, experimental and theoretical efforts have provided evidence that cholesterol has unique abilities to increase the order of lipid packing (1–4), lower the permeability (5, 6), and maintain the fluidity and diffusion rate (1, 2, 4) at the same time.
  • It increases the lipid-packing density and maintains high membrane fluidity.
  • cholesterol significantly increases the order of the lipid packing, lowers the membrane permeability, and maintains membrane fluidity by forming liquid-ordered–phase lipid rafts.

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