The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy | Proceedings of the National Academy of Sciences thumbnail
The atomic structure of adeno-associated virus (AAV-2), a vector for human gene therapy | Proceedings of the National Academy of Sciences
www.pnas.org
Positively charged patches are common in heparin-binding proteins (47) because of the predominance of ionic interactions with the sugar sulfate The primary receptor for AAV-2 on the cell surface is heparan sulfate proteoglycan, but other receptors may also be available as alternates or secondary rec
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  • Positively charged patches are common in heparin-binding proteins (47) because of the predominance of ionic interactions with the sugar sulfate
  • The primary receptor for AAV-2 on the cell surface is heparan sulfate proteoglycan, but other receptors may also be available as alternates or secondary receptors (
  • the outside surface is positively charged with a prominent ring of symmetry-related patches in a depression surrounding the fivefold axes
  • Residues 448-RGNR-451 on the valley rim are unique to AAV-2,
  • he electrostatic receptor interactions with these residues would be more subtle than in many heparin-binding proteins,

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