Positively charged patches are common in heparin-binding proteins (47) because of the predominance of ionic interactions with the sugar sulfate
The primary receptor for AAV-2 on the cell surface is heparan sulfate proteoglycan, but other receptors may also be available as alternates or secondary receptors (
the outside surface is positively charged with a prominent ring of symmetry-related patches in a depression surrounding the fivefold axes
Residues 448-RGNR-451 on the valley rim are unique to AAV-2,
he electrostatic receptor interactions with these residues would be more subtle than in many heparin-binding proteins,
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