Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α | PNAS thumbnail
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-γ coactivator 1α | PNAS
www.pnas.org
PGC-1α and numerous genes regulated by PGC-1α are repressed in models of cardiac stress PGC-1α repression may contribute to the maladaptive response of the heart to chronic hemodynamic loads Treating cardiac cells in tissue culture with the catecholamine epinephrine leads to repression of PGC-1α PGC
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  • PGC-1α and numerous genes regulated by PGC-1α are repressed in models of cardiac stress
  • PGC-1α repression may contribute to the maladaptive response of the heart to chronic hemodynamic loads
  • Treating cardiac cells in tissue culture with the catecholamine epinephrine leads to repression of PGC-1α
  • PGC-1α is abundantly expressed in the heart
  • Conversely, we have recently shown that ablation of the PGC-1α gene caused important deficiencies in cardiac energy reserves and function

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