Strong overexpression of the genes involved in cholesterol transport and signaling pathways (i.e., APOA4 and APOE) as well as in peroxisomal genes regulating intracellular cholesterol transport (i.e., ABCD1, PEX5, PEX11) and in exosomes biogenesis and release further shows that communication via exosomes is strongly activated during ED (Fig. 3E)
Exosome bio- genesis, multivesicular bodies transport, and exosome release as well as extracellular and intracellular vesicles are all processes most affected during ED,
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