DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics | Proceedings of the National Academy of Sciences thumbnail
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics | Proceedings of the National Academy of Sciences
www.pnas.org
facilitates mitochondrial fission and lipid homeostasis adipocyte-specific DNA methylation, manifested in enhancers and CTCF sites, directs distal enhancer-mediated transcriptomic features required to conserve metabolic functions of white adipocytes DNMT1 maintains metabolic fitness of adipocytes th
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  • facilitates mitochondrial fission and lipid homeostasis
  • adipocyte-specific DNA methylation, manifested in enhancers and CTCF sites, directs distal enhancer-mediated transcriptomic features required to conserve metabolic functions of white adipocytes
  • DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics
  • genetic ablation of adipocyte Dnmt1, the major methylation writer, led to increased adiposity characterized by increased adipocyte hypertrophy along with reduced expansion of adipocyte precursors (APs)
  • Dnmt1 deficiency provoked systemic hyperlipidemia and impaired energy metabolism both in lean and obese mice.

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