Voltage-induced calcium release in Caenorhabditis elegans body muscles | PNAS thumbnail
Voltage-induced calcium release in Caenorhabditis elegans body muscles | PNAS
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n voltage-induced calcium release (VICR), CaV1 voltage sensing domains are directly coupled to ryanodine receptors (RYRs), an SR calcium channel. I calcium-induced calcium release (CICR), calcium ions flowing through activated CaV1 channels bind and activate RYR channels Here, we use calcium-activat
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  • n voltage-induced calcium release (VICR), CaV1 voltage sensing domains are directly coupled to ryanodine receptors (RYRs), an SR calcium channel. I
  • calcium-induced calcium release (CICR), calcium ions flowing through activated CaV1 channels bind and activate RYR channels
  • Here, we use calcium-activated SLO-2 potassium channels to analyze CaV1-SR coupling in Caenorhabditis elegans body muscles.
  • VICR-mediated SLO-2 activation requires two SR calcium channels (RYRs and IP3 Receptors),
  • These results suggest that EGL-19 and SR calcium release are both required for SLO-2 activation

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