Gephyrin promotes autonomous assembly and synaptic localization of GABAergic postsynaptic components without presynaptic GABA release | PNAS thumbnail
Gephyrin promotes autonomous assembly and synaptic localization of GABAergic postsynaptic components without presynaptic GABA release | PNAS
www.pnas.org
γ-aminobutyric acid (GABA) is a major neurotransmitter that plays a critical inhibitory role in regulating the cellular excitability of neurons. GABA is biosynthesized by glutamate decarboxylase enzymes (i.e., GAD65 and GAD67), packaged into secretory vesicles by the GABA transporter (i.e., vGAT), r
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  • γ-aminobutyric acid (GABA) is a major neurotransmitter that plays a critical inhibitory role in regulating the cellular excitability of neurons. GABA is biosynthesized by glutamate decarboxylase enzymes (i.e., GAD65 and GAD67), packaged into secretory vesicles by the GABA transporter (i.e., vGAT), released from presynaptic terminals, and activates ...
  • proteins that affect their formation and/or maturation
  • Gephyrin is an important component that self-aggregates beneath the cell membrane and anchors several factors involved in synapse development
  • various cytoskeletal components [e.g., Dynein, G-actin, Profilin, and Mena; (8, 9)], a Rho family guanine nucleotide exchange factor (Rho-GEF) Collybistin [ARHGEF9; human homolog hPEM-2; (10, 11)], synaptic cell-adhesion molecule (CAM) Neuroligin-2 [NLGN2; (12, 13)],
  • catalyzes a cis-trans conformational switch in its substrates including NLGN2

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