Both GlyR and GABAAR are neurotransmitter receptors exclusively expressed at inhibitory synapses that directly interact with the gephyrin E domain through their cytoplasmic loops (51–54). Notably, the loop-binding site on the E domain is located away from a dimerizing interface between E domains (54), indicating that loop binding occurs at the spac...
we first characterized the overall phase behaviors of gephyrin in cells as well as the contribution of individual gephyrin domains to condensation.
revealed that the linker-mediated phase separation is not attributable to IDR–IDR interactions, but rather originates from the conformational collapse of the linker as well as electrostatic interdomain interactions.
differentially modulate the stability of gephyrin condensation,
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