Thermodynamic modulation of gephyrin condensation by inhibitory synapse components | Proceedings of the National Academy of Sciences thumbnail
Thermodynamic modulation of gephyrin condensation by inhibitory synapse components | Proceedings of the National Academy of Sciences
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Both GlyR and GABAAR are neurotransmitter receptors exclusively expressed at inhibitory synapses that directly interact with the gephyrin E domain through their cytoplasmic loops (51–54). Notably, the loop-binding site on the E domain is located away from a dimerizing interface between E domains (54
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  • Both GlyR and GABAAR are neurotransmitter receptors exclusively expressed at inhibitory synapses that directly interact with the gephyrin E domain through their cytoplasmic loops (51–54). Notably, the loop-binding site on the E domain is located away from a dimerizing interface between E domains (54), indicating that loop binding occurs at the spac...
  • we first characterized the overall phase behaviors of gephyrin in cells as well as the contribution of individual gephyrin domains to condensation.
  • revealed that the linker-mediated phase separation is not attributable to IDR–IDR interactions, but rather originates from the conformational collapse of the linker as well as electrostatic interdomain interactions.
  • differentially modulate the stability of gephyrin condensation,
  • polyphasic linkage formalism

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