Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice | PNAS thumbnail
Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice | PNAS
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Both approaches resulted in extensive WGA expression in the cell bodies and dendrites of neurons in which the recombination event occurred, as well as anterograde and transneuronal transport of the lectin to second and third order neurons. Purkinje cell-specific promoter, L7 To induce the WGA transg
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  • Both approaches resulted in extensive WGA expression in the cell bodies and dendrites of neurons in which the recombination event occurred, as well as anterograde and transneuronal transport of the lectin to second and third order neurons.
  • Purkinje cell-specific promoter, L7
  • To induce the WGA transgene, either we crossed these mice with others that express Cre recombinase under the control of tissue-specific promoters, or we microinjected an adeno-associated virus (AAV) that expresses Cre.

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