The proteins found in the outer membrane of Gram-negative bacteria, generally have a highly similar β-barrel fold (1), which has evolved mostly by replication of an ancestral hairpin motif
there are significant differences in amino acid abundance at different depths across the membrane, with more hydrophobic residues in the central region of the membrane
The TMBB-DB (31) contains 1,881,712 sequences collected from 600 different bacterial proteomes with sequences ranked by their likelihood of encoding a TMBB
OMPdb (32) contains 1,198,558 (as of Jan 2021) protein sequences predicted to be TMBBs by the PRED-TMBB2 algorithm.
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