A proprioceptive feedback circuit drives Caenorhabditis elegans locomotor adaptation through dopamine signaling | PNAS thumbnail
A proprioceptive feedback circuit drives Caenorhabditis elegans locomotor adaptation through dopamine signaling | PNAS
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We found that the worm responds to optogenetically or mechanically induced decreases in midbody bending amplitude by increasing its anterior amplitude. Conversely, it responds to increased midbody amplitude by decreasing the anterior amplitude The dopaminergic PDE neurons proprioceptively sense midb
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  • We found that the worm responds to optogenetically or mechanically induced decreases in midbody bending amplitude by increasing its anterior amplitude.
  • Conversely, it responds to increased midbody amplitude by decreasing the anterior amplitude
  • The dopaminergic PDE neurons proprioceptively sense midbody bending and signal to AVK interneurons via the D2-like dopamine receptor DOP-3. The FMRFamide-like neuropeptide FLP-1, released by AVK, regulates SMB head motor neurons to modulate anterior bending
  • PVD releases the NLP-12 neuropeptide from its dendrites when it is proprioceptively triggered by local body bending, which is thought to regulate the amplitude of body movements
  • we found that C. elegans uses a posterior-to-anterior proprioceptive feedback loop to adapt its locomotor amplitude to perturbations

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