TRAIL–DR-mediated ryanodine receptor activation and endocytosis is dependent on early caspase-8 activation.
Dynamins are master regulators of CME
Binding of human recombinant TRAIL to its cognate apoptosis-inducing DR (DR4 or DR5) stimulates their internalization via CME
Taken together, our findings confirm previous reports (21, 22) of an important role for TRAIL–DR endocytosis in the negative regulation of TRAIL-induced apoptosis, and furthermore, establish the existence of cargo-selective, dynamin isoform-specific mechanisms for endocytosis.
Dyn1 can also be activated through dephosphorylation by the calcium (Ca2+) and calmodulin-dependent phosphatase, calcineurin (29, 30). Inhibiting calcineurin by either cyclosporin A (CsA) (Fig. 2B) or FK506 (Fig. S4), resulted in a significant increase in sensitivity to TRAIL-induced apoptosis in A549 WT cells, comparable to the levels seen in Dyn1...
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