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PtdIns(4,5)P2 signaling regulates ATG14 and autophagy | Proceedings of the National Academy of Sciences thumbnail
PtdIns(4,5)P2 signaling regulates ATG14 and autophagy | Proceedings of the National Academy of Sciences
www.pnas.org
proving clinical therapeutics. Phosphatidylinositol 3-phosphate [PtdIns(3)P] is a key lipid messenger directly involved in autophagy initiation. Here we discovered that PtdIns(4,5)P2 plays an equally important role in autophagy. The autophagy-related protein 14 (ATG14) specifically interacts with PI
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  • proving clinical therapeutics. Phosphatidylinositol 3-phosphate [PtdIns(3)P] is a key lipid messenger directly involved in autophagy initiation. Here we discovered that PtdIns(4,5)P2 plays an equally important role in autophagy. The autophagy-related protein 14 (ATG14) specifically interacts with PIPKIγi5, a PtdIns(4,5)P2 generating enzyme that con...

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