. As a result, the abundant cFLIPL forms enzymatically active heterodimers with caspase 8 (CASP8) in MSMs, which prevents formation of proapoptotic CASP8 p10/p20 and cleaves receptor interacting protein kinase 1 (RIP1), thus setting up a higher threshold for CD95-mediated apoptosis and RIP1-mediated necroptosis.
The rs557036049 SNP is highlighted in yellow because the underrepresented allele (G) is not preferred by the U2 snRNP and thus may decrease the binding efficacy of this protein, which is crucial for initiating splicing
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