The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center | Proceedings of the National Academy of Sciences thumbnail
The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center | Proceedings of the National Academy of Sciences
www.pnas.org
D-amino acids are synthesized by racemase enzymes and can be found at high concentrations in cells the D-aa-tRNA deacylase (DTD) enzyme is nearly universally conserved and functions to remove D-amino acids that have been misacylated onto tRNA Once an aa-tRNA has been incorporated into the ribosomal
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  • D-amino acids are synthesized by racemase enzymes
  • and can be found at high concentrations in cells
  • the D-aa-tRNA deacylase (DTD) enzyme is nearly universally conserved
  • and functions to remove D-amino acids that have been misacylated onto tRNA
  • Once an aa-tRNA has been incorporated into the ribosomal aa-tRNA binding (A) site, the ribosome positions the carbonyl carbon of the ester bond linking the nascent polypeptide to the peptidyl-tRNA bound at the ribosomal peptidyl-tRNA binding (P) site for nucleophilic attack by the α-amino group of the amino acid moiety of the newly incorporated A-s...

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