HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila | Proceedings of the National Academy of Sciences thumbnail
HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila | Proceedings of the National Academy of Sciences
www.pnas.org
Accordingly, MT-stabilizing drugs such as paclitaxel and epothilone D have been shown as possible therapies for AD and related tauopathies. However, MT-stabilizing drugs have common side effects such as neuropathy and neutropenia. Overexpressed tau was hyperphosphorylated and resulted in decreased M
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  • Accordingly, MT-stabilizing drugs such as paclitaxel and epothilone D have been shown as possible therapies for AD and related tauopathies. However, MT-stabilizing drugs have common side effects such as neuropathy and neutropenia.
  • Overexpressed tau was hyperphosphorylated and resulted in decreased MT density and greater fragmentation
  • Genetic and pharmacological inhibition of the tubulin-specific deacetylase activity of HDAC6 indicates that the rescue effect may be mediated by increased MT acetylation.

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tau
HDAC6
neurodegeneration
MT
AD

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