The formate channel FocA exports the products of mixed-acid fermentation | Proceedings of the National Academy of Sciences thumbnail
The formate channel FocA exports the products of mixed-acid fermentation | Proceedings of the National Academy of Sciences
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The related formate channel FocA attains a very different physiological role, because it is produced during anaerobic mixed-acid fermentation We conducted a detailed electrophysiological analysis of anion transport by the formate channel FocA, with the result that the protein exclusively transports
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  • The related formate channel FocA attains a very different physiological role, because it is produced during anaerobic mixed-acid fermentation
  • We conducted a detailed electrophysiological analysis of anion transport by the formate channel FocA, with the result that the protein exclusively transports monovalent anions
  • albeit with unexpectedly low specificity for the ion itself.
  • This experiment confirmed the specificity of FocA for formate and provided evidence that other monovalent anions can traverse the membrane through this channel.
  • pyruvate:formate lyase (PFL) converts pyruvate, the product of glycolysis, to acetyl-CoA and releases formate (HCOO–) that must be removed from the cytoplasm to avoid intracellular accumulation. The anion is exported via FocA

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