The related formate channel FocA attains a very different physiological role, because it is produced during anaerobic mixed-acid fermentation
We conducted a detailed electrophysiological analysis of anion transport by the formate channel FocA, with the result that the protein exclusively transports monovalent anions
albeit with unexpectedly low specificity for the ion itself.
This experiment confirmed the specificity of FocA for formate and provided evidence that other monovalent anions can traverse the membrane through this channel.
pyruvate:formate lyase (PFL) converts pyruvate, the product of glycolysis, to acetyl-CoA and releases formate (HCOO–) that must be removed from the cytoplasm to avoid intracellular accumulation. The anion is exported via FocA
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