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Toll-like receptor 4 signaling in T cells promotes autoimmune inflammation | Proceedings of the National Academy of Sciences
www.pnas.org
a tendency for naïve cells to proliferate more extensively when LPS was added to the cultures naïve CD4+ T cells with LPS alone induced proliferation compared with untreated cells At suboptimal doses of αCD3, LPS enhanced proliferation, but at larger doses this effect was minimal. TLR4 signaling in
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a tendency for naïve cells to proliferate more extensively when LPS was added to the cultures
naïve CD4+ T cells with LPS alone induced proliferation compared with untreated cells
At suboptimal doses of αCD3, LPS enhanced proliferation, but at larger doses this effect was minimal.
TLR4 signaling in CD4+ T cells acts to enhance activation in the absence of TcR stimulation and promote survival.
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