human MSCs in a highly malignant and invasive model of glioblastoma.
MSCs are resistant to the cytokine tumor necrosis factor apoptosis ligand (TRAIL) and, when engineered to express secreted recombinant TRAIL, induce caspase-mediated apoptosis in established glioma cell lines as well as CD133-positive primary glioma cells in vitro
engineered MSCs have been shown to exert potent inhibition of tumor growth in an in vivo glioma model and also exhibit a protective effect for the normal brain
engineered lentiviral vectors bearing fluorescent and bioluminescent markers to stably label stem cells and tumor cells to study their fate in real time in vitro and in vivo
reduced proliferation rate compared with non-transduced cells over several passages in culture
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