Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy
www.pnas.org
This high resistance to a drug that damages the DNA of dividing cells, particularly blood cells, would be consistent with the entry of most or all of the normally dividing cells into a high-protection/cell-cycle-arrested mode in response to the 48- to 60-h starvation Model for DSR in response to STS
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- This high resistance to a drug that damages the DNA of dividing cells, particularly blood cells, would be consistent with the entry of most or all of the normally dividing cells into a high-protection/cell-cycle-arrested mode in response to the 48- to 60-h starvation
- Model for DSR in response to STS. In normal cells, downstream elements of the IGF1 and other growth factor pathways, including the Akt, Ras, and other proto-oncogenes, are down-regulated in response to the reduction in growth factors caused by starvation.
- ammals, starvation causes a reduction in IGF1 signaling, which is associated with increased stress resistanc
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