Universal DNA methylation age across mammalian tissues - Nature Aging thumbnail
Universal DNA methylation age across mammalian tissues - Nature Aging
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Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consort
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  • Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks
  • demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium
  • predictive models estimate mammalian tissue age with high accuracy (r > 0.96)
  • Age deviations correlate with human mortality risk
  • mouse somatotropic axis mutations and caloric restriction

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