Targeting inflammation in atherosclerosis — from experimental insights to the clinic - Nature Reviews Drug Discovery thumbnail
Targeting inflammation in atherosclerosis — from experimental insights to the clinic - Nature Reviews Drug Discovery
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clinical studies have now demonstrated unequivocally that modulation of inflammation can forestall the clinical complications of atherosclerosis including targeting pivotal inflammatory pathways such as the inflammasomes manipulating adaptive immunity the ensuing inflammatory response orchestrates t
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  • clinical studies have now demonstrated unequivocally that modulation of inflammation can forestall the clinical complications of atherosclerosis
  • including targeting pivotal inflammatory pathways such as the inflammasomes
  • manipulating adaptive immunity
  • the ensuing inflammatory response orchestrates the progression and outcome of the disease.
  • This study targeted a specific pro-inflammatory cytokine, IL-1β, which has been implicated in atherogenesis through decades of experimental work. CANTOS showed that administration of an anti-IL-1β antibody to patients who were cardiovascularly stable after a myocardial infarction and were being treated according to current guidelines (including wit...

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