Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins - Nature Immunology thumbnail
Defining the antibody cross-reactome directed against the influenza virus surface glycoproteins - Nature Immunology
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Better understanding of cross-reactive immunity in the human population is also important for the development of universal vaccine strategies against influenza virus that are designed to boost pre-existing antibodies to protective levels. Then, we compared antibody responses after infection of human
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  • Better understanding of cross-reactive immunity in the human population is also important for the development of universal vaccine strategies against influenza virus that are designed to boost pre-existing antibodies to protective levels.
  • Then, we compared antibody responses after infection of humans with influenza virus H1N1 or H3N2 and found markedly broad responses and cogent evidence for 'original antigenic sin'
  • However, they usually induce strain-specific immune responses to the three to four strains included in the vaccine formulatio
  • We found that the cross-reactivity profiles depended on the pre-exposure history and were influenced by the viral strains first encountered during childhood.
  • showed high reactivity to very recent isolates of these two subtypes, with limited cross-reactivity

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