Mitotic progression following DNA damage enables pattern recognition within micronuclei - Nature thumbnail
Mitotic progression following DNA damage enables pattern recognition within micronuclei - Nature
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STAT1 phosphorylation at Y701 inflammatory pathway activation after ionizing radiation failure of non-homologous end-joining (NHEJ) DSB repair should amplify the response nhibition of DNA-dependent protein kinase catalytic subunit (DNA-PKi) or CRISPR–Cas9 knockout of multiple NHEJ components diminis
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Top Highlights

  • STAT1 phosphorylation at Y701
  • inflammatory pathway activation after ionizing radiation
  • failure of non-homologous end-joining (NHEJ) DSB repair should amplify the response
  • nhibition of DNA-dependent protein kinase catalytic subunit (DNA-PKi) or CRISPR–Cas9 knockout of multiple NHEJ components diminished STAT1 activation
  • DSB-induced STAT1 activation correlated with the appearance of aberrantly shaped nuclei and micronuclei

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