Frontiers | Cariprazine in the Treatment of Bipolar Disorder: Within and Beyond Clinical Trials
www.frontiersin.org
Although cariprazine has been studied as a monotherapy agent in bipolar disorder, it can be administered concurrently with lithium, valproic acid or lamotrigine with no dose adjustment required. The dose of cariprazine should be reduced by 50% when administered concurrently with strong CYP3A4 inhibi
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- Although cariprazine has been studied as a monotherapy agent in bipolar disorder, it can be administered concurrently with lithium, valproic acid or lamotrigine with no dose adjustment required.
- The dose of cariprazine should be reduced by 50% when administered concurrently with strong CYP3A4 inhibitors (27).
- Cariprazine was shown to be generally well-tolerated
- adverse events
- The most common cariprazine TEAEs were akathisia, extrapyramidal symptoms
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