Frontiers | Role of Mitochondrial Reverse Electron Transport in ROS Signaling: Potential Roles in Health and Disease
www.frontiersin.org
The current consensus is that the amount of ROS determines their physiological effects, with low levels of ROS having beneficial effects through stimulation of mitohormesis and high levels causing oxidative damage and contributing to aging. In the last 10 years, the development of new technology and
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- The current consensus is that the amount of ROS determines their physiological effects, with low levels of ROS having beneficial effects through stimulation of mitohormesis and high levels causing oxidative damage and contributing to aging. In the last 10 years, the development of new technology and methods has allowed the measurement of mtROS leve...
- Mitochondrial reactive oxygen species (mtROS) produced by the respiratory chain (RC) during oxidative phosphorylation are the main source of free radicals in most cell types
- The scientific community has changed its opinion of ROS over the last 15 years. Initially ROS were described as simple by-products of metabolism that caused oxidative damage and were responsible for damage upon ischemia-reperfusion or chronic diseases such as Parkinson's or Alzheimer's disease as well as aging (Sanz et al., 2006). However, an incre...
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